2HK1

Crystal structure of D-psicose 3-epimerase (DPEase) in the presence of D-fructose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016853	molecular_function	isomerase activity
A	0016857	molecular_function	racemase and epimerase activity, acting on carbohydrates and derivatives
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
A	0050897	molecular_function	cobalt ion binding
B	0016853	molecular_function	isomerase activity
B	0016857	molecular_function	racemase and epimerase activity, acting on carbohydrates and derivatives
B	0030145	molecular_function	manganese ion binding
B	0046872	molecular_function	metal ion binding
B	0050897	molecular_function	cobalt ion binding
C	0016853	molecular_function	isomerase activity
C	0016857	molecular_function	racemase and epimerase activity, acting on carbohydrates and derivatives
C	0030145	molecular_function	manganese ion binding
C	0046872	molecular_function	metal ion binding
C	0050897	molecular_function	cobalt ion binding
D	0016853	molecular_function	isomerase activity
D	0016857	molecular_function	racemase and epimerase activity, acting on carbohydrates and derivatives
D	0030145	molecular_function	manganese ion binding
D	0046872	molecular_function	metal ion binding
D	0050897	molecular_function	cobalt ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE FUD A 1300

Chain	Residue
A	ILE66
A	ARG215
A	GLU244
A	MN1004
A	GLY67
A	GLY106
A	ALA107
A	GLU150
A	GLU156
A	ASP183
A	HIS186
A	HIS209

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1004

Chain	Residue
A	GLU150
A	ASP183
A	HIS209
A	GLU244
A	FUD1300

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE FUD B 1301

Chain	Residue
B	ILE66
B	GLY67
B	GLY106
B	ALA107
B	GLU150
B	GLU156
B	ASP183
B	HIS186
B	HIS209
B	ARG215
B	GLU244
B	MN1002

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN B 1002

Chain	Residue
B	GLU150
B	ASP183
B	HIS209
B	GLU244
B	FUD1301

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE FUD C 1302

Chain	Residue
C	ILE66
C	GLY67
C	GLY106
C	ALA107
C	GLU150
C	GLU156
C	ASP183
C	HIS186
C	HIS209
C	ARG215
C	GLU244
C	MN1003

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 1003

Chain	Residue
C	GLU150
C	ASP183
C	HIS209
C	GLU244
C	FUD1302

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE FUD D 1303

Chain	Residue
D	ILE66
D	GLY67
D	GLY106
D	ALA107
D	GLU150
D	LEU152
D	GLU156
D	ASP183
D	HIS186
D	HIS209
D	ARG215
D	GLU244
D	MN1001

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN D 1001

Chain	Residue
D	GLU150
D	ASP183
D	HIS209
D	GLU244
D	FUD1303

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:Q9WYP7

Chain	Residue	Details
A	GLU150
A	GLU244
B	GLU150
B	GLU244
C	GLU150
C	GLU244
D	GLU150
D	GLU244

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:B8I944

Chain	Residue	Details
A	TYR6
B	TYR6
C	TYR6
D	TYR6

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269|PubMed:16876192

Chain	Residue	Details
A	HIS209
A	ARG215
A	GLU244
B	ALA107
B	GLU150
B	GLU156
B	ASP183
B	HIS209
B	ARG215
B	GLU244
C	ALA107
C	GLU150
C	GLU156
C	ASP183
C	HIS209
C	ARG215
C	GLU244
D	ALA107
D	GLU150
D	GLU156
D	ASP183
D	HIS209
D	ARG215
D	GLU244
A	ALA107
A	GLU150
A	GLU156
A	ASP183

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