2GWC
Crystal structure of plant glutamate cysteine ligase in complex with a transition state analogue
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004357 | molecular_function | glutamate-cysteine ligase activity |
| A | 0006750 | biological_process | glutathione biosynthetic process |
| A | 0042398 | biological_process | cellular modified amino acid biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004357 | molecular_function | glutamate-cysteine ligase activity |
| B | 0006750 | biological_process | glutathione biosynthetic process |
| B | 0042398 | biological_process | cellular modified amino acid biosynthetic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004357 | molecular_function | glutamate-cysteine ligase activity |
| C | 0006750 | biological_process | glutathione biosynthetic process |
| C | 0042398 | biological_process | cellular modified amino acid biosynthetic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004357 | molecular_function | glutamate-cysteine ligase activity |
| D | 0006750 | biological_process | glutathione biosynthetic process |
| D | 0042398 | biological_process | cellular modified amino acid biosynthetic process |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004357 | molecular_function | glutamate-cysteine ligase activity |
| E | 0006750 | biological_process | glutathione biosynthetic process |
| E | 0042398 | biological_process | cellular modified amino acid biosynthetic process |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004357 | molecular_function | glutamate-cysteine ligase activity |
| F | 0006750 | biological_process | glutathione biosynthetic process |
| F | 0042398 | biological_process | cellular modified amino acid biosynthetic process |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004357 | molecular_function | glutamate-cysteine ligase activity |
| G | 0006750 | biological_process | glutathione biosynthetic process |
| G | 0042398 | biological_process | cellular modified amino acid biosynthetic process |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004357 | molecular_function | glutamate-cysteine ligase activity |
| H | 0006750 | biological_process | glutathione biosynthetic process |
| H | 0042398 | biological_process | cellular modified amino acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1 |
| Chain | Residue |
| A | BSC2 |
| A | GLU107 |
| A | GLU159 |
| A | GLU165 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 1 |
| Chain | Residue |
| B | BSC2 |
| B | GLU107 |
| B | GLU159 |
| B | GLU165 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 1 |
| Chain | Residue |
| C | GLU107 |
| C | GLU159 |
| C | GLU165 |
| C | BSC2 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 1 |
| Chain | Residue |
| D | BSC2 |
| D | GLU107 |
| D | GLU159 |
| D | GLU165 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG E 1 |
| Chain | Residue |
| E | BSC2 |
| E | GLU107 |
| E | GLU159 |
| E | GLU165 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG F 1 |
| Chain | Residue |
| F | BSC2 |
| F | GLU107 |
| F | GLU159 |
| F | GLU165 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG G 1 |
| Chain | Residue |
| G | BSC2 |
| G | GLU107 |
| G | GLU159 |
| G | GLU165 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG H 1 |
| Chain | Residue |
| H | BSC2 |
| H | GLU107 |
| H | GLU159 |
| H | GLU165 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE BSC A 2 |
| Chain | Residue |
| A | MG1 |
| A | GLU107 |
| A | GLU159 |
| A | PRO160 |
| A | THR242 |
| A | CYS243 |
| A | THR244 |
| A | ARG292 |
| A | TRP296 |
| A | PHE375 |
| A | ARG387 |
| A | HOH571 |
| site_id | BC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE BSC B 2 |
| Chain | Residue |
| B | MG1 |
| B | GLU107 |
| B | GLU159 |
| B | PRO160 |
| B | MSE224 |
| B | MSE238 |
| B | THR242 |
| B | CYS243 |
| B | THR244 |
| B | ARG292 |
| B | TRP296 |
| B | PHE375 |
| B | ARG387 |
| B | HOH560 |
| site_id | BC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE BSC C 2 |
| Chain | Residue |
| C | MG1 |
| C | GLU107 |
| C | GLU159 |
| C | PRO160 |
| C | MSE224 |
| C | MSE238 |
| C | THR242 |
| C | CYS243 |
| C | THR244 |
| C | ARG292 |
| C | TRP296 |
| C | PHE375 |
| C | ARG387 |
| C | HOH531 |
| site_id | BC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE BSC D 2 |
| Chain | Residue |
| D | MG1 |
| D | GLU107 |
| D | GLU159 |
| D | PRO160 |
| D | MSE224 |
| D | THR242 |
| D | CYS243 |
| D | THR244 |
| D | ARG292 |
| D | TRP296 |
| D | PHE375 |
| D | ARG387 |
| D | HOH534 |
| site_id | BC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE BSC E 2 |
| Chain | Residue |
| E | HOH586 |
| E | MG1 |
| E | GLU107 |
| E | GLU159 |
| E | PRO160 |
| E | MSE224 |
| E | MSE238 |
| E | THR242 |
| E | CYS243 |
| E | THR244 |
| E | ARG292 |
| E | TRP296 |
| E | PHE375 |
| E | ARG387 |
| E | HOH520 |
| site_id | BC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE BSC F 2 |
| Chain | Residue |
| F | MG1 |
| F | GLU107 |
| F | GLU159 |
| F | PRO160 |
| F | MSE224 |
| F | THR242 |
| F | CYS243 |
| F | THR244 |
| F | ARG292 |
| F | TRP296 |
| F | PHE375 |
| F | ARG387 |
| F | HOH542 |
| site_id | BC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE BSC G 2 |
| Chain | Residue |
| G | MG1 |
| G | GLU107 |
| G | GLU159 |
| G | PRO160 |
| G | MSE224 |
| G | THR242 |
| G | CYS243 |
| G | THR244 |
| G | ARG292 |
| G | TRP296 |
| G | PHE375 |
| G | ARG387 |
| G | HOH549 |
| G | HOH626 |
| site_id | BC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE BSC H 2 |
| Chain | Residue |
| H | MG1 |
| H | GLU107 |
| H | GLU159 |
| H | MSE224 |
| H | THR242 |
| H | CYS243 |
| H | THR244 |
| H | ARG292 |
| H | TRP296 |
| H | PHE375 |
| H | ARG387 |
| H | HOH523 |
