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2FMX

An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003400biological_processregulation of COPII vesicle coating
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006886biological_processintracellular protein transport
A0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016050biological_processvesicle organization
A0016192biological_processvesicle-mediated transport
A0016787molecular_functionhydrolase activity
A0030127cellular_componentCOPII vesicle coat
A0032368biological_processregulation of lipid transport
A0032580cellular_componentGolgi cisterna membrane
A0042953biological_processlipoprotein transport
A0046872molecular_functionmetal ion binding
A0048208biological_processCOPII vesicle coating
A0055088biological_processlipid homeostasis
A0061024biological_processmembrane organization
A0070863biological_processpositive regulation of protein exit from endoplasmic reticulum
A0070971cellular_componentendoplasmic reticulum exit site
A0090110biological_processCOPII-coated vesicle cargo loading
A0140353biological_processlipid export from cell
B0003400biological_processregulation of COPII vesicle coating
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006886biological_processintracellular protein transport
B0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016050biological_processvesicle organization
B0016192biological_processvesicle-mediated transport
B0016787molecular_functionhydrolase activity
B0030127cellular_componentCOPII vesicle coat
B0032368biological_processregulation of lipid transport
B0032580cellular_componentGolgi cisterna membrane
B0042953biological_processlipoprotein transport
B0046872molecular_functionmetal ion binding
B0048208biological_processCOPII vesicle coating
B0055088biological_processlipid homeostasis
B0061024biological_processmembrane organization
B0070863biological_processpositive regulation of protein exit from endoplasmic reticulum
B0070971cellular_componentendoplasmic reticulum exit site
B0090110biological_processCOPII-coated vesicle cargo loading
B0140353biological_processlipid export from cell
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 4770
ChainResidue
APHE18
AGLY185
ATYR186
AGLY187
AGLU188
AARG191
AHOH4781
AHOH4856

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 4771
ChainResidue
BGLY185
BTYR186
BGLY187
BGLU188
BARG191
BHOH4795
BPHE18

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 504
ChainResidue
BTHR39
BGDP2568
BHOH4773
BHOH4794
BHOH4826

site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE GDP A 2567
ChainResidue
AASP34
AASN35
AALA36
AGLY37
ALYS38
ATHR39
ATHR40
AASN134
ALYS135
AASP137
ASER179
AVAL180
ALEU181
AHOH4808
AHOH4830
AHOH4845
AHOH4857

site_idAC5
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GDP B 2568
ChainResidue
BLEU33
BASN35
BALA36
BGLY37
BLYS38
BTHR39
BTHR40
BASN134
BLYS135
BASP137
BARG138
BSER179
BVAL180
BLEU181
BMG504
BHOH4794
BHOH4826
BHOH4863

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:11739406, ECO:0007744|PDB:1F6B
ChainResidueDetails
BHIS58
BASP75
BASN134
BVAL180
AASP34
AHIS58
AASP75
AASN134
AVAL180
BASP34

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Y6B6
ChainResidueDetails
ASER164
BSER164

219869

PDB entries from 2024-05-15

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