2FK3

Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'large unit cell' form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0046914	molecular_function	transition metal ion binding
B	0016020	cellular_component	membrane
B	0046914	molecular_function	transition metal ion binding
C	0016020	cellular_component	membrane
C	0046914	molecular_function	transition metal ion binding
D	0016020	cellular_component	membrane
D	0046914	molecular_function	transition metal ion binding
E	0016020	cellular_component	membrane
E	0046914	molecular_function	transition metal ion binding
F	0016020	cellular_component	membrane
F	0046914	molecular_function	transition metal ion binding
G	0016020	cellular_component	membrane
G	0046914	molecular_function	transition metal ion binding
H	0016020	cellular_component	membrane
H	0046914	molecular_function	transition metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CU C 201

Chain	Residue
C	HIS137
G	HIS137
G	HOH190

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CU C 202

Chain	Residue
C	GLU131
H	HIS137
H	GLU139

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CU B 203

Chain	Residue
B	HIS137
D	HIS137

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 204

Chain	Residue
A	GLU139
A	HOH237
G	GLU131
A	HIS137

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU E 205

Chain	Residue
D	GLU131
E	HIS137
E	GLU139
E	HOH238

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CU F 206

Chain	Residue
B	GLU131
F	HIS137
F	GLU139

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CU H 207

Chain	Residue
E	HOH224
E	HOH225
E	HOH226
H	HOH212
H	HOH213
H	HOH214

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU A 208

Chain	Residue
A	HOH214
A	HOH217
A	HOH218
F	HOH220
F	HOH221

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU H 209

Chain	Residue
H	HOH223
H	HOH224
H	HOH231
H	HOH232

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CU C 210

Chain	Residue
C	HOH244

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CU A 211

Chain	Residue
A	HOH235
A	HOH236
A	HOH237

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU E 212

Chain	Residue
E	LEU165
E	HIS166
H	LEU165
H	HIS166
H	HOH213

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 213

Chain	Residue
A	LEU165
A	HIS166
F	LEU165
F	HIS166

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CU B 214

Chain	Residue
B	TYR168
C	TYR168

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU D 215

Chain	Residue
D	TYR168
D	HOH229
G	TYR168
G	HOH209

---

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CU D 216

Chain	Residue
E	HOH221

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU F 217

Chain	Residue
F	SER159
F	THR163
F	ASN164
F	HOH222

---

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CU F 219

Chain	Residue
A	HOH227

---

Functional Information from PROSITE/UniProt

site_id	PS00319
Number of Residues	8
Details	APP_CUBD Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. GVEFVCCP

Chain	Residue	Details
A	GLY181-PRO188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1

Chain	Residue	Details
A	HIS147
E	HIS151
F	HIS147
F	HIS151
G	HIS147
G	HIS151
H	HIS147
H	HIS151
A	HIS151
B	HIS147
B	HIS151
C	HIS147
C	HIS151
D	HIS147
D	HIS151
E	HIS147

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0007744|PDB:2FK1

Chain	Residue	Details
A	TYR168
B	TYR168
C	TYR168
D	TYR168
E	TYR168
F	TYR168
G	TYR168
H	TYR168

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000305|PubMed:8344894

Chain	Residue	Details
A	GLU183
D	GLU183
D	CYS186
D	CYS187
E	GLU183
E	CYS186
E	CYS187
F	GLU183
F	CYS186
F	CYS187
G	GLU183
A	CYS186
G	CYS186
G	CYS187
H	GLU183
H	CYS186
H	CYS187
A	CYS187
B	GLU183
B	CYS186
B	CYS187
C	GLU183
C	CYS186
C	CYS187

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	SITE: Required for Cu(2+) reduction => ECO:0000255|PROSITE-ProRule:PRU01217

Chain	Residue	Details
A	MET170
B	MET170
C	MET170
D	MET170
E	MET170
F	MET170
G	MET170
H	MET170

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