2EHH

Crystal structure of dihydrodipicolinate synthase from aquifex aeolicus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
A	0009085	biological_process	lysine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0016829	molecular_function	lyase activity
A	0019877	biological_process	diaminopimelate biosynthetic process
A	0044281	biological_process	small molecule metabolic process
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
C	0009085	biological_process	lysine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0016829	molecular_function	lyase activity
C	0019877	biological_process	diaminopimelate biosynthetic process
C	0044281	biological_process	small molecule metabolic process
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
D	0009085	biological_process	lysine biosynthetic process
D	0009089	biological_process	lysine biosynthetic process via diaminopimelate
D	0016829	molecular_function	lyase activity
D	0019877	biological_process	diaminopimelate biosynthetic process
D	0044281	biological_process	small molecule metabolic process
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
E	0009085	biological_process	lysine biosynthetic process
E	0009089	biological_process	lysine biosynthetic process via diaminopimelate
E	0016829	molecular_function	lyase activity
E	0019877	biological_process	diaminopimelate biosynthetic process
E	0044281	biological_process	small molecule metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 1001

Chain	Residue
A	TYR105
A	HOH1003
A	HOH1077
A	HOH1083
C	ASN79
C	TYR105

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 E 1002

Chain	Residue
E	HOH1004
E	HOH1084
D	ASN79
D	TYR105
E	TYR105

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Functional Information from PROSITE/UniProt

site_id	PS00665
Number of Residues	18
Details	DHDPS_1 Dihydrodipicolinate synthase signature 1. AILvcGTTGESptltfeE

Chain	Residue	Details
A	ALA37-GLU54

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site_id	PS00666
Number of Residues	32
Details	DHDPS_2 Dihydrodipicolinate synthase signature 2. YNIPsrTcveIsvdtmfklasecenIvASKES

Chain	Residue	Details
A	TYR132-SER163

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00418

Chain	Residue	Details
A	TYR132
C	TYR132
D	TYR132
E	TYR132

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000255|HAMAP-Rule:MF_00418

Chain	Residue	Details
A	LYS161
C	LYS161
D	LYS161
E	LYS161

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00418

Chain	Residue	Details
A	THR44
D	THR44
D	ILE203
E	THR44
E	ILE203
A	ILE203
C	THR44
C	ILE203

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	SITE: Part of a proton relay during catalysis => ECO:0000255|HAMAP-Rule:MF_00418

Chain	Residue	Details
D	THR43
D	TYR106
E	THR43
E	TYR106
A	THR43
A	TYR106
C	THR43
C	TYR106

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