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2E32

Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase

Functional Information from GO Data
ChainGOidnamespacecontents
A0001540molecular_functionamyloid-beta binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0006511biological_processubiquitin-dependent protein catabolic process
A0006516biological_processglycoprotein catabolic process
A0008285biological_processnegative regulation of cell population proliferation
A0016020cellular_componentmembrane
A0016567biological_processprotein ubiquitination
A0019005cellular_componentSCF ubiquitin ligase complex
A0030246molecular_functioncarbohydrate binding
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031249molecular_functiondenatured protein binding
A0031396biological_processregulation of protein ubiquitination
A0036503biological_processERAD pathway
A0043197cellular_componentdendritic spine
A0043231cellular_componentintracellular membrane-bounded organelle
A0061630molecular_functionubiquitin protein ligase activity
A0098890cellular_componentextrinsic component of postsynaptic membrane
A0098978cellular_componentglutamatergic synapse
A0099576biological_processregulation of protein catabolic process at postsynapse, modulating synaptic transmission
B0000209biological_processprotein polyubiquitination
B0000278biological_processmitotic cell cycle
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0006338biological_processchromatin remodeling
B0006511biological_processubiquitin-dependent protein catabolic process
B0006513biological_processprotein monoubiquitination
B0008013molecular_functionbeta-catenin binding
B0016567biological_processprotein ubiquitination
B0019005cellular_componentSCF ubiquitin ligase complex
B0019904molecular_functionprotein domain specific binding
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031467cellular_componentCul7-RING ubiquitin ligase complex
B0031519cellular_componentPcG protein complex
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0051457biological_processmaintenance of protein location in nucleus
B0070936biological_processprotein K48-linked ubiquitination
B0097602molecular_functioncullin family protein binding
B0140677molecular_functionmolecular function activator activity
B0160072molecular_functionubiquitin ligase complex scaffold activity
B1904668biological_processpositive regulation of ubiquitin protein ligase activity
B1990444molecular_functionF-box domain binding
B1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
C0001540molecular_functionamyloid-beta binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0006511biological_processubiquitin-dependent protein catabolic process
C0006516biological_processglycoprotein catabolic process
C0008285biological_processnegative regulation of cell population proliferation
C0016020cellular_componentmembrane
C0016567biological_processprotein ubiquitination
C0019005cellular_componentSCF ubiquitin ligase complex
C0030246molecular_functioncarbohydrate binding
C0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C0031249molecular_functiondenatured protein binding
C0031396biological_processregulation of protein ubiquitination
C0036503biological_processERAD pathway
C0043197cellular_componentdendritic spine
C0043231cellular_componentintracellular membrane-bounded organelle
C0061630molecular_functionubiquitin protein ligase activity
C0098890cellular_componentextrinsic component of postsynaptic membrane
C0098978cellular_componentglutamatergic synapse
C0099576biological_processregulation of protein catabolic process at postsynapse, modulating synaptic transmission
D0000209biological_processprotein polyubiquitination
D0000278biological_processmitotic cell cycle
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0006338biological_processchromatin remodeling
D0006511biological_processubiquitin-dependent protein catabolic process
D0006513biological_processprotein monoubiquitination
D0008013molecular_functionbeta-catenin binding
D0016567biological_processprotein ubiquitination
D0019005cellular_componentSCF ubiquitin ligase complex
D0019904molecular_functionprotein domain specific binding
D0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0031467cellular_componentCul7-RING ubiquitin ligase complex
D0031519cellular_componentPcG protein complex
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0051457biological_processmaintenance of protein location in nucleus
D0070936biological_processprotein K48-linked ubiquitination
D0097602molecular_functioncullin family protein binding
D0140677molecular_functionmolecular function activator activity
D0160072molecular_functionubiquitin ligase complex scaffold activity
D1904668biological_processpositive regulation of ubiquitin protein ligase activity
D1990444molecular_functionF-box domain binding
D1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
BPRO132
DPRO132
CARG214
CTYR279

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211
ChainResidueDetails
BASN143
APHE177
DASN143
CPHE177

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER106
CSER106

218853

PDB entries from 2024-04-24

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