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2E30

Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001578biological_processmicrotubule bundle formation
A0001933biological_processnegative regulation of protein phosphorylation
A0004860molecular_functionprotein kinase inhibitor activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006469biological_processnegative regulation of protein kinase activity
A0006611biological_processprotein export from nucleus
A0006813biological_processpotassium ion transport
A0007264biological_processsmall GTPase-mediated signal transduction
A0008017molecular_functionmicrotubule binding
A0010923biological_processnegative regulation of phosphatase activity
A0012505cellular_componentendomembrane system
A0015031biological_processprotein transport
A0015385molecular_functionsodium:proton antiporter activity
A0015459molecular_functionpotassium channel regulator activity
A0015630cellular_componentmicrotubule cytoskeleton
A0019900molecular_functionkinase binding
A0022406biological_processmembrane docking
A0030133cellular_componenttransport vesicle
A0031122biological_processcytoplasmic microtubule organization
A0031397biological_processnegative regulation of protein ubiquitination
A0031953biological_processnegative regulation of protein autophosphorylation
A0032088biological_processnegative regulation of NF-kappaB transcription factor activity
A0032417biological_processpositive regulation of sodium:proton antiporter activity
A0035725biological_processsodium ion transmembrane transport
A0042308biological_processnegative regulation of protein import into nucleus
A0045121cellular_componentmembrane raft
A0046872molecular_functionmetal ion binding
A0048306molecular_functioncalcium-dependent protein binding
A0050821biological_processprotein stabilization
A0051222biological_processpositive regulation of protein transport
A0051453biological_processregulation of intracellular pH
A0060050biological_processpositive regulation of protein glycosylation
A0061024biological_processmembrane organization
A0061025biological_processmembrane fusion
A0070062cellular_componentextracellular exosome
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071073biological_processpositive regulation of phospholipid biosynthetic process
A0071468biological_processcellular response to acidic pH
A0090314biological_processpositive regulation of protein targeting to membrane
A1990351cellular_componenttransporter complex
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 300
ChainResidue
AASP123
AASP125
ALYS126
AASP127
ALYS129
AGLU134

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE CA A 301
ChainResidue
AGLY167
AASP168
AALA170
AILE171
AGLU175
AASP164
AGLN165
AASP166

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
ALYS126
AGLU128
AILE130
ALEU135
ALEU124
AGLN165
AGLY167
ASER169
APHE176

site_idSWS_FT_FI2
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805
ChainResidueDetails
ASER3

219869

PDB entries from 2024-05-15

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