2DZB

Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in complex with 6HMPPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004156	molecular_function	dihydropteroate synthase activity
A	0005829	cellular_component	cytosol
A	0009396	biological_process	folic acid-containing compound biosynthetic process
A	0016740	molecular_function	transferase activity
A	0042558	biological_process	pteridine-containing compound metabolic process
A	0044237	biological_process	cellular metabolic process
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046656	biological_process	folic acid biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0004156	molecular_function	dihydropteroate synthase activity
B	0005829	cellular_component	cytosol
B	0009396	biological_process	folic acid-containing compound biosynthetic process
B	0016740	molecular_function	transferase activity
B	0042558	biological_process	pteridine-containing compound metabolic process
B	0044237	biological_process	cellular metabolic process
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046656	biological_process	folic acid biosynthetic process
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HH2 A 1301

Chain	Residue
A	VAL34
A	LYS233
A	ARG268
A	HIS270
A	HOH1309
A	HOH1351
A	HOH1358
A	ASN36
A	ASP109
A	ASN128
A	MET152
A	ASP197
A	PHE202
A	LEU227
A	GLY229

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site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HH2 B 1302

Chain	Residue
B	VAL34
B	ASN36
B	THR76
B	ASP109
B	ASN128
B	VAL150
B	MET152
B	ASP197
B	PHE202
B	LEU227
B	GLY229
B	LYS233
B	ARG268
B	HIS270
B	HOH1304
B	HOH1331
B	HOH1451

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Functional Information from PROSITE/UniProt

site_id	PS00792
Number of Residues	16
Details	DHPS_1 Dihydropteroate synthase signature 1. LlGVLNlTpDSFsDgG

Chain	Residue	Details
A	LEU31-GLY46

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site_id	PS00793
Number of Residues	14
Details	DHPS_2 Dihydropteroate synthase signature 2. GAdILDLGAesTrP

Chain	Residue	Details
A	GLY65-PRO78

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