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2DXS

Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE JTP A 1000
ChainResidue
AVAL37
AVAL494
APRO495
ATRP500
AARG503
ALEU392
AALA393
AALA395
AALA396
ALEU425
AHIS428
APHE429
AGLY493

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE JTP B 2000
ChainResidue
BVAL37
BLEU392
BALA393
BALA395
BALA396
BHIS428
BLEU492
BGLY493
BVAL494
BPRO495
BTRP500
BARG503

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572
ChainResidueDetails
ATHR221
AASP319
ALEU320
BTHR221
BASP319
BLEU320

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by serine protease/helicase NS3 => ECO:0000250|UniProtKB:P27958
ChainResidueDetails
BSER1
ASER1

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ALEU30
AARG43
BLEU30
BARG43

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PDB entries from 2024-06-12

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