Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2CYD

Crystal structure of Lithium bound rotor ring of the V-ATPase from Enterococcus hirae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006814	biological_process	sodium ion transport
A	0015078	molecular_function	proton transmembrane transporter activity
A	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
A	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
A	0042802	molecular_function	identical protein binding
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0006814	biological_process	sodium ion transport
B	0015078	molecular_function	proton transmembrane transporter activity
B	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
B	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
B	0042802	molecular_function	identical protein binding
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0006814	biological_process	sodium ion transport
C	0015078	molecular_function	proton transmembrane transporter activity
C	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
C	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
C	0042802	molecular_function	identical protein binding
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0006814	biological_process	sodium ion transport
D	0015078	molecular_function	proton transmembrane transporter activity
D	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
D	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
D	0042802	molecular_function	identical protein binding
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005886	cellular_component	plasma membrane
E	0006814	biological_process	sodium ion transport
E	0015078	molecular_function	proton transmembrane transporter activity
E	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
E	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
E	0042802	molecular_function	identical protein binding
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005886	cellular_component	plasma membrane
F	0006814	biological_process	sodium ion transport
F	0015078	molecular_function	proton transmembrane transporter activity
F	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
F	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
F	0042802	molecular_function	identical protein binding
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005886	cellular_component	plasma membrane
G	0006814	biological_process	sodium ion transport
G	0015078	molecular_function	proton transmembrane transporter activity
G	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
G	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
G	0042802	molecular_function	identical protein binding
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0005886	cellular_component	plasma membrane
H	0006814	biological_process	sodium ion transport
H	0015078	molecular_function	proton transmembrane transporter activity
H	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
H	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
H	0042802	molecular_function	identical protein binding
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport
I	0005886	cellular_component	plasma membrane
I	0006814	biological_process	sodium ion transport
I	0015078	molecular_function	proton transmembrane transporter activity
I	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
I	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
I	0042802	molecular_function	identical protein binding
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0005886	cellular_component	plasma membrane
J	0006814	biological_process	sodium ion transport
J	0015078	molecular_function	proton transmembrane transporter activity
J	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
J	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
J	0042802	molecular_function	identical protein binding
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI A 157

Chain	Residue
A	LEU61
A	PRO62
A	THR64
A	GLN65
A	GLN110
A	GLU139

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI B 157

Chain	Residue
B	GLN65
B	GLN110
B	GLU139
B	LEU61
B	PRO62
B	THR64

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI C 157

Chain	Residue
C	LEU61
C	PRO62
C	THR64
C	GLN65
C	GLN110
C	GLU139

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI D 157

Chain	Residue
D	LEU61
D	PRO62
D	THR64
D	GLN65
D	GLN110
D	GLU139

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI E 157

Chain	Residue
E	LEU61
E	PRO62
E	THR64
E	GLN65
E	GLN110
E	GLU139

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI F 157

Chain	Residue
F	LEU61
F	PRO62
F	THR64
F	GLN65
F	GLN110
F	GLU139

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI G 157

Chain	Residue
G	LEU61
G	PRO62
G	THR64
G	GLN65
G	GLN110
G	GLU139

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI H 157

Chain	Residue
H	LEU61
H	PRO62
H	THR64
H	GLN65
H	GLN110
H	GLU139

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI I 157

Chain	Residue
I	LEU61
I	PRO62
I	THR64
I	GLN65
I	GLN110
I	GLU139

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LI J 157

Chain	Residue
J	LEU61
J	PRO62
J	THR64
J	GLN65
J	GLN110
J	GLU139

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LHG A 558

Chain	Residue
A	LEU17
A	THR21
A	LYS32
A	PHE105
B	LYS32
J	PHE101
J	PHE105

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LHG A 559

Chain	Residue
A	MET1
A	MET2
A	LEU17
B	LHG1159
J	LHG9158
J	LHG9159

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LHG B 1158

Chain	Residue
A	PHE105
B	LEU17
B	THR21
B	LYS32
B	HOH1163
C	LYS32

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG B 1159

Chain	Residue
A	LHG559
B	MET1
B	MET2
B	LEU17
C	LHG2159

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LHG C 2158

Chain	Residue
C	LEU17
C	THR21
C	LYS32
D	LYS32

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG C 2159

Chain	Residue
B	LHG1159
C	MET1
C	MET2
C	LEU17
D	LHG3159

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LHG D 3158

Chain	Residue
E	LYS32
C	PHE105
D	LEU17
D	THR21
D	LYS32
D	PHE105
D	HOH3180

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG D 3159

Chain	Residue
C	LHG2159
D	MET1
D	MET2
D	LEU17
E	LHG4159

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG E 4158

Chain	Residue
E	LEU17
E	THR21
E	LYS32
E	PHE105
F	LYS32

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG E 4159

Chain	Residue
D	LHG3159
E	MET1
E	MET2
E	LEU17
F	LHG5159

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LHG F 5158

Chain	Residue
F	LEU17
F	THR21
F	LYS32
F	HOH5164
G	LYS32
G	LHG6159

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG F 5159

Chain	Residue
E	LHG4159
F	MET1
F	MET2
F	LEU17
G	LHG6159

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LHG G 6158

Chain	Residue
F	PHE105
G	LEU17
G	THR21
G	LYS32
G	PHE105
H	LYS32

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LHG G 6159

Chain	Residue
F	LHG5158
F	LHG5159
G	MET1
G	MET2
G	LEU17
H	LHG7159

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LHG H 7158

Chain	Residue
H	LEU17
H	THR21
H	LYS32
H	PHE105
H	HOH7164
I	LYS32

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG H 7159

Chain	Residue
G	LHG6159
H	MET1
H	MET2
H	LEU17
I	LHG8159

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG I 8158

Chain	Residue
I	LEU17
I	THR21
I	LYS32
I	PHE105
J	LYS32

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LHG I 8159

Chain	Residue
H	LHG7159
I	MET1
I	MET2
I	VAL13
I	LEU17
J	LHG9159

site_id	DC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE LHG J 9158

Chain	Residue
A	LYS32
A	LHG559
J	LEU17
J	THR21
J	LYS32
J	LEU104
J	PHE105
J	HOH9175

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LHG J 9159

Chain	Residue
A	LHG559
I	LHG8159
J	MET2
J	LEU17

site_id	DC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE UMQ C 1001

Chain	Residue
C	GLN54
C	PRO125
C	THR129
F	LYS123
F	LYS124
F	PRO125
F	GLU126

site_id	DC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE UMQ F 1002

Chain	Residue
C	LYS123
C	LYS124
C	PRO125
C	GLU126
F	GLN54
F	PRO125
F	THR129

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	800
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
B	GLY89-ALA109
B	ILE132-LEU152
C	GLY11-ALA31
C	LEU60-LEU80
C	GLY89-ALA109
C	ILE132-LEU152
D	GLY11-ALA31
D	LEU60-LEU80
D	GLY89-ALA109
D	ILE132-LEU152
E	GLY11-ALA31
E	LEU60-LEU80
E	GLY89-ALA109
E	ILE132-LEU152
F	GLY11-ALA31
F	LEU60-LEU80
F	GLY89-ALA109
F	ILE132-LEU152
G	GLY11-ALA31
G	LEU60-LEU80
G	GLY89-ALA109
G	ILE132-LEU152
H	GLY11-ALA31
H	LEU60-LEU80
H	GLY89-ALA109
H	ILE132-LEU152
I	GLY11-ALA31
I	LEU60-LEU80
I	GLY89-ALA109
I	ILE132-LEU152
J	GLY11-ALA31
J	LEU60-LEU80
J	GLY89-ALA109
J	ILE132-LEU152
A	GLY11-ALA31
A	LEU60-LEU80
A	GLY89-ALA109
A	ILE132-LEU152
B	GLY11-ALA31
B	LEU60-LEU80

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)