Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2CLB

The structure of the DPS-like protein from Sulfolobus solfataricus reveals a bacterioferritin-like di-metal binding site within a Dps- like dodecameric assembly

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006880	biological_process	intracellular sequestering of iron ion
A	0008199	molecular_function	ferric iron binding
A	0009295	cellular_component	nucleoid
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
B	0004322	molecular_function	ferroxidase activity
B	0005506	molecular_function	iron ion binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006880	biological_process	intracellular sequestering of iron ion
B	0008199	molecular_function	ferric iron binding
B	0009295	cellular_component	nucleoid
B	0016491	molecular_function	oxidoreductase activity
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
C	0004322	molecular_function	ferroxidase activity
C	0005506	molecular_function	iron ion binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006880	biological_process	intracellular sequestering of iron ion
C	0008199	molecular_function	ferric iron binding
C	0009295	cellular_component	nucleoid
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
D	0004322	molecular_function	ferroxidase activity
D	0005506	molecular_function	iron ion binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006880	biological_process	intracellular sequestering of iron ion
D	0008199	molecular_function	ferric iron binding
D	0009295	cellular_component	nucleoid
D	0016491	molecular_function	oxidoreductase activity
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
M	0004322	molecular_function	ferroxidase activity
M	0005506	molecular_function	iron ion binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006880	biological_process	intracellular sequestering of iron ion
M	0008199	molecular_function	ferric iron binding
M	0009295	cellular_component	nucleoid
M	0016491	molecular_function	oxidoreductase activity
M	0020037	molecular_function	heme binding
M	0046872	molecular_function	metal ion binding
N	0004322	molecular_function	ferroxidase activity
N	0005506	molecular_function	iron ion binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006880	biological_process	intracellular sequestering of iron ion
N	0008199	molecular_function	ferric iron binding
N	0009295	cellular_component	nucleoid
N	0016491	molecular_function	oxidoreductase activity
N	0020037	molecular_function	heme binding
N	0046872	molecular_function	metal ion binding
O	0004322	molecular_function	ferroxidase activity
O	0005506	molecular_function	iron ion binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006879	biological_process	intracellular iron ion homeostasis
O	0006880	biological_process	intracellular sequestering of iron ion
O	0008199	molecular_function	ferric iron binding
O	0009295	cellular_component	nucleoid
O	0016491	molecular_function	oxidoreductase activity
O	0020037	molecular_function	heme binding
O	0046872	molecular_function	metal ion binding
P	0004322	molecular_function	ferroxidase activity
P	0005506	molecular_function	iron ion binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006879	biological_process	intracellular iron ion homeostasis
P	0006880	biological_process	intracellular sequestering of iron ion
P	0008199	molecular_function	ferric iron binding
P	0009295	cellular_component	nucleoid
P	0016491	molecular_function	oxidoreductase activity
P	0020037	molecular_function	heme binding
P	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1175

Chain	Residue
A	GLU37
A	ASP70
A	HIS73
A	GLU156

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE A1176

Chain	Residue
A	ASP70
A	GLU124
A	GLU156
A	HIS159
A	HOH2012

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B1175

Chain	Residue
B	GLU37
B	ASP70
B	HIS73
B	GLU156

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE B1176

Chain	Residue
B	ASP70
B	GLU124
B	GLU156
B	HIS159
B	HOH2005

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C1175

Chain	Residue
C	GLU37
C	ASP70
C	HIS73
C	GLU156

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE C1176

Chain	Residue
C	ASP70
C	GLU124
C	GLU156
C	HIS159
C	HOH2007

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D1175

Chain	Residue
D	GLU37
D	ASP70
D	HIS73
D	GLU156

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE D1176

Chain	Residue
D	ASP70
D	GLU124
D	GLU156
D	HIS159
D	HOH2014

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN M1175

Chain	Residue
M	GLU37
M	ASP70
M	HIS73
M	GLU156
M	FE1176

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE M1176

Chain	Residue
M	ASP70
M	GLU124
M	GLU156
M	HIS159
M	ZN1175
M	HOH2014

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN N1175

Chain	Residue
N	GLU37
N	ASP70
N	HIS73
N	GLU156

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE N1176

Chain	Residue
N	ASP70
N	GLU124
N	GLU156
N	HIS159
N	HOH2004

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN O1175

Chain	Residue
O	GLU37
O	ASP70
O	HIS73
O	GLU156
O	FE1176

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE O1176

Chain	Residue
O	ASP70
O	GLU124
O	GLU156
O	HIS159
O	ZN1175
O	HOH2007

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P1175

Chain	Residue
P	GLU37
P	ASP70
P	HIS73
P	GLU156

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE P1176

Chain	Residue
P	ASP70
P	GLU124
P	GLU156
P	HIS159
P	HOH2015

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	GLU37
B	HIS159
C	GLU37
C	HIS73
C	GLU124
C	GLU156
C	HIS159
D	GLU37
D	HIS73
D	GLU124
D	GLU156
A	HIS73
D	HIS159
M	GLU37
M	HIS73
M	GLU124
M	GLU156
M	HIS159
N	GLU37
N	HIS73
N	GLU124
N	GLU156
A	GLU124
N	HIS159
O	GLU37
O	HIS73
O	GLU124
O	GLU156
O	HIS159
P	GLU37
P	HIS73
P	GLU124
P	GLU156
A	GLU156
P	HIS159
A	HIS159
B	GLU37
B	HIS73
B	GLU124
B	GLU156

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)