2CF2
Architecture of mammalian fatty acid synthase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0044281 | biological_process | small molecule metabolic process |
| A | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0008693 | molecular_function | (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| J | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005829 | cellular_component | cytosol |
| J | 0006633 | biological_process | fatty acid biosynthetic process |
| J | 0016746 | molecular_function | acyltransferase activity |
| J | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| J | 0044281 | biological_process | small molecule metabolic process |
| J | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
| K | 0016740 | molecular_function | transferase activity |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006633 | biological_process | fatty acid biosynthetic process |
| L | 0008693 | molecular_function | (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity |
| M | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348, ECO:0000305|PubMed:10571059 |
| Chain | Residue | Details |
| A | SER163 | |
| J | SER163 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 |
| Chain | Residue | Details |
| A | HIS298 | |
| A | HIS333 | |
| J | HIS298 | |
| J | HIS333 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 292 |
| Chain | Residue | Details |
| A | SER163 | activator, covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile |
| A | HIS298 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | LYS328 | activator, hydrogen bond donor |
| A | HIS333 | electrostatic stabiliser, hydrogen bond donor, increase basicity |
| A | PHE390 | activator, hydrogen bond acceptor |
| A | PHE392 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 292 |
| Chain | Residue | Details |
| J | SER163 | activator, covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile |
| J | HIS298 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| J | LYS328 | activator, hydrogen bond donor |
| J | HIS333 | electrostatic stabiliser, hydrogen bond donor, increase basicity |
| J | PHE390 | activator, hydrogen bond acceptor |
| J | PHE392 | electrostatic stabiliser, hydrogen bond donor |
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | VAL1076 | |
| C | GLY1079 | |
| C | HIS1070 | |
| C | CYS1080 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| L | ASP1084 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| L | VAL1076 | |
| L | GLY1079 | |
| L | HIS1070 | |
| L | CYS1080 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | ASP1084 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | SER97 | |
| B | HIS201 | |
| B | GLN250 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| K | SER97 | |
| K | HIS201 | |
| K | GLN250 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| D | TYR49 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| M | TYR49 |
| site_id | CSA9 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | PHE392 | |
| A | LYS328 | |
| A | HIS298 | |
| A | HIS333 | |
| A | PHE390 | |
| A | SER163 |
| site_id | CSA10 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| J | PHE392 | |
| J | LYS328 | |
| J | HIS298 | |
| J | HIS333 | |
| J | PHE390 | |
| J | SER163 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| E | LYS155 | |
| E | TYR151 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| E | LYS155 | |
| E | GLN148 |
| site_id | CSA13 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| N | LYS155 | |
| N | GLN148 |
| site_id | CSA14 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| N | LYS155 | |
| N | TYR151 |
