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2C9S

1.24 Angstroms resolution structure of Zn-Zn Human Superoxide dismutase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0000303biological_processresponse to superoxide
A0001541biological_processovarian follicle development
A0001819biological_processpositive regulation of cytokine production
A0001890biological_processplacenta development
A0001895biological_processretina homeostasis
A0002262biological_processmyeloid cell homeostasis
A0004784molecular_functionsuperoxide dismutase activity
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005758cellular_componentmitochondrial intermembrane space
A0005759cellular_componentmitochondrial matrix
A0005777cellular_componentperoxisome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006749biological_processglutathione metabolic process
A0006801biological_processsuperoxide metabolic process
A0006879biological_processintracellular iron ion homeostasis
A0006915biological_processapoptotic process
A0006979biological_processresponse to oxidative stress
A0007283biological_processspermatogenesis
A0007566biological_processembryo implantation
A0007605biological_processsensory perception of sound
A0007626biological_processlocomotory behavior
A0008089biological_processanterograde axonal transport
A0008090biological_processretrograde axonal transport
A0008217biological_processregulation of blood pressure
A0008270molecular_functionzinc ion binding
A0008340biological_processdetermination of adult lifespan
A0009408biological_processresponse to heat
A0009410biological_processresponse to xenobiotic stimulus
A0010033biological_processresponse to organic substance
A0010467biological_processgene expression
A0016209molecular_functionantioxidant activity
A0016491molecular_functionoxidoreductase activity
A0019226biological_processtransmission of nerve impulse
A0019228biological_processneuronal action potential
A0019430biological_processremoval of superoxide radicals
A0030346molecular_functionprotein phosphatase 2B binding
A0031267molecular_functionsmall GTPase binding
A0031410cellular_componentcytoplasmic vesicle
A0032287biological_processperipheral nervous system myelin maintenance
A0032839cellular_componentdendrite cytoplasm
A0032930biological_processpositive regulation of superoxide anion generation
A0032991cellular_componentprotein-containing complex
A0033081biological_processregulation of T cell differentiation in thymus
A0035234biological_processectopic germ cell programmed cell death
A0040014biological_processregulation of multicellular organism growth
A0042542biological_processresponse to hydrogen peroxide
A0042554biological_processsuperoxide anion generation
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043085biological_processpositive regulation of catalytic activity
A0043087biological_processregulation of GTPase activity
A0043410biological_processpositive regulation of MAPK cascade
A0043524biological_processnegative regulation of neuron apoptotic process
A0045471biological_processresponse to ethanol
A0045541biological_processnegative regulation of cholesterol biosynthetic process
A0045859biological_processregulation of protein kinase activity
A0046620biological_processregulation of organ growth
A0046716biological_processmuscle cell cellular homeostasis
A0046872molecular_functionmetal ion binding
A0048538biological_processthymus development
A0048678biological_processresponse to axon injury
A0050665biological_processhydrogen peroxide biosynthetic process
A0050728biological_processnegative regulation of inflammatory response
A0050766biological_processpositive regulation of phagocytosis
A0051087molecular_functionprotein-folding chaperone binding
A0051093biological_processnegative regulation of developmental process
A0051881biological_processregulation of mitochondrial membrane potential
A0060047biological_processheart contraction
A0060052biological_processneurofilament cytoskeleton organization
A0060087biological_processrelaxation of vascular associated smooth muscle
A0060088biological_processauditory receptor cell stereocilium organization
A0070062cellular_componentextracellular exosome
A0072593biological_processreactive oxygen species metabolic process
A0099610biological_processaction potential initiation
A1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1904115cellular_componentaxon cytoplasm
A2000242biological_processnegative regulation of reproductive process
F0000302biological_processresponse to reactive oxygen species
F0000303biological_processresponse to superoxide
F0001541biological_processovarian follicle development
F0001819biological_processpositive regulation of cytokine production
F0001890biological_processplacenta development
F0001895biological_processretina homeostasis
F0002262biological_processmyeloid cell homeostasis
F0004784molecular_functionsuperoxide dismutase activity
F0005507molecular_functioncopper ion binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005758cellular_componentmitochondrial intermembrane space
F0005759cellular_componentmitochondrial matrix
F0005777cellular_componentperoxisome
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006749biological_processglutathione metabolic process
F0006801biological_processsuperoxide metabolic process
F0006879biological_processintracellular iron ion homeostasis
F0006915biological_processapoptotic process
F0006979biological_processresponse to oxidative stress
F0007283biological_processspermatogenesis
F0007566biological_processembryo implantation
F0007605biological_processsensory perception of sound
F0007626biological_processlocomotory behavior
F0008089biological_processanterograde axonal transport
F0008090biological_processretrograde axonal transport
F0008217biological_processregulation of blood pressure
F0008270molecular_functionzinc ion binding
F0008340biological_processdetermination of adult lifespan
F0009408biological_processresponse to heat
F0009410biological_processresponse to xenobiotic stimulus
F0010033biological_processresponse to organic substance
F0010467biological_processgene expression
F0016209molecular_functionantioxidant activity
F0016491molecular_functionoxidoreductase activity
F0019226biological_processtransmission of nerve impulse
F0019228biological_processneuronal action potential
F0019430biological_processremoval of superoxide radicals
F0030346molecular_functionprotein phosphatase 2B binding
F0031267molecular_functionsmall GTPase binding
F0031410cellular_componentcytoplasmic vesicle
F0032287biological_processperipheral nervous system myelin maintenance
F0032839cellular_componentdendrite cytoplasm
F0032930biological_processpositive regulation of superoxide anion generation
F0032991cellular_componentprotein-containing complex
F0033081biological_processregulation of T cell differentiation in thymus
F0035234biological_processectopic germ cell programmed cell death
F0040014biological_processregulation of multicellular organism growth
F0042542biological_processresponse to hydrogen peroxide
F0042554biological_processsuperoxide anion generation
F0042802molecular_functionidentical protein binding
F0043025cellular_componentneuronal cell body
F0043065biological_processpositive regulation of apoptotic process
F0043066biological_processnegative regulation of apoptotic process
F0043085biological_processpositive regulation of catalytic activity
F0043087biological_processregulation of GTPase activity
F0043410biological_processpositive regulation of MAPK cascade
F0043524biological_processnegative regulation of neuron apoptotic process
F0045471biological_processresponse to ethanol
F0045541biological_processnegative regulation of cholesterol biosynthetic process
F0045859biological_processregulation of protein kinase activity
F0046620biological_processregulation of organ growth
F0046716biological_processmuscle cell cellular homeostasis
F0046872molecular_functionmetal ion binding
F0048538biological_processthymus development
F0048678biological_processresponse to axon injury
F0050665biological_processhydrogen peroxide biosynthetic process
F0050728biological_processnegative regulation of inflammatory response
F0050766biological_processpositive regulation of phagocytosis
F0051087molecular_functionprotein-folding chaperone binding
F0051093biological_processnegative regulation of developmental process
F0051881biological_processregulation of mitochondrial membrane potential
F0060047biological_processheart contraction
F0060052biological_processneurofilament cytoskeleton organization
F0060087biological_processrelaxation of vascular associated smooth muscle
F0060088biological_processauditory receptor cell stereocilium organization
F0070062cellular_componentextracellular exosome
F0072593biological_processreactive oxygen species metabolic process
F0099610biological_processaction potential initiation
F1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
F1904115cellular_componentaxon cytoplasm
F2000242biological_processnegative regulation of reproductive process
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A1155
ChainResidue
AHIS46
AHIS48
AHIS63
AHIS120
ASO41161

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A1156
ChainResidue
AHIS63
AHIS71
AHIS80
AASP83

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A1157
ChainResidue
ASER142
AARG143
ASO41163
AHOH2229
AHOH2245

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ACT A1158
ChainResidue
AGLU132
AACT1159
AHOH2230
AHOH2231
FGLU132
FHOH2218
FHOH2223

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ACT A1159
ChainResidue
AGLU132
AACT1158
AHOH2201
AHOH2230
AHOH2232
AHOH2233
FGLU132

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A1160
ChainResidue
AGLU40
AARG69
ALYS91
AHOH2072
AHOH2101
AHOH2135
AHOH2235
AHOH2236

site_idAC7
Number of Residues12
DetailsBINDING SITE FOR RESIDUE SO4 A1161
ChainResidue
AHIS46
AHIS48
AHIS63
AHIS120
ATHR137
AARG143
AZN1155
AHOH2211
AHOH2214
AHOH2237
AHOH2238
AHOH2242

site_idAC8
Number of Residues10
DetailsBINDING SITE FOR RESIDUE SO4 A1162
ChainResidue
AGLU133
AASN139
AALA140
AGLY141
AHOH2212
AHOH2214
AHOH2239
AHOH2240
AHOH2241
AHOH2242

site_idAC9
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A1163
ChainResidue
ATHR58
AARG143
AZN1157
AHOH2229
AHOH2244
AHOH2245
AHOH2246
AHOH2247

site_idBC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE SO4 F1154
ChainResidue
FHIS46
FHIS48
FHIS63
FHIS120
FTHR137
FARG143
FZN1157
FHOH2229
FHOH2231
FHOH2248
FHOH2249
FHOH2250
FHOH2251

site_idBC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 F1155
ChainResidue
FTHR58
FSER142
FARG143
FZN1160
FHOH2252
FHOH2253
FHOH2255

site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN F1157
ChainResidue
FHIS46
FHIS48
FHIS63
FHIS120
FSO41154

site_idBC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F1158
ChainResidue
FHIS63
FHIS71
FHIS80
FASP83

site_idBC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ACT F1159
ChainResidue
FHOH2257
FHOH2258
FHOH2259
FPRO74
FGLY85
FASN86
FLEU126

site_idBC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN F1160
ChainResidue
FSER142
FARG143
FLEU144
FSO41155
FHOH2260

Functional Information from PROSITE/UniProt
site_idPS00087
Number of Residues11
DetailsSOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHEfGDnT
ChainResidueDetails
AGLY44-THR54

site_idPS00332
Number of Residues12
DetailsSOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGsRlACgvI
ChainResidueDetails
AGLY138-ILE149

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:12963370, ECO:0000269|PubMed:17548825
ChainResidueDetails
AVAL47
AGLU49
AGLU121
FVAL47
FGLU49
FGLU121

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:20727846
ChainResidueDetails
APHE64
AGLY72
AVAL81
ALEU84
FPHE64
FGLY72
FVAL81
FLEU84

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:1463506, ECO:0000269|PubMed:7002610, ECO:0007744|PubMed:25944712
ChainResidueDetails
ATHR2
FTHR2

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P08228
ChainResidueDetails
AALA4
AGLY10
AASP92
FALA4
FGLY10
FASP92

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569
ChainResidueDetails
AILE99
FILE99

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
AVAL103
FVAL103

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07632
ChainResidueDetails
ALEU106
FLEU106

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08228
ChainResidueDetails
AGLY108
FGLY108

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:24140062
ChainResidueDetails
AALA123
FALA123

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P08228
ChainResidueDetails
ATHR137
FTHR137

site_idSWS_FT_FI11
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:22496122
ChainResidueDetails
AVAL7
FVAL7

site_idSWS_FT_FI12
Number of Residues4
DetailsCROSSLNK: 1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33) => ECO:0000269|PubMed:20600836
ChainResidueDetails
AGLY33
FGLY33

218853

PDB entries from 2024-04-24

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