2C13
5-hydroxy-levulinic acid bound to Porphobilinogen synthase from Pseudomonas aeruginosa
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004655 | molecular_function | porphobilinogen synthase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
A | 0006783 | biological_process | heme biosynthetic process |
A | 0008270 | molecular_function | zinc ion binding |
A | 0016829 | molecular_function | lyase activity |
A | 0033014 | biological_process | tetrapyrrole biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
B | 0004655 | molecular_function | porphobilinogen synthase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
B | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
B | 0006783 | biological_process | heme biosynthetic process |
B | 0008270 | molecular_function | zinc ion binding |
B | 0016829 | molecular_function | lyase activity |
B | 0033014 | biological_process | tetrapyrrole biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG A1336 |
Chain | Residue |
A | ARG181 |
A | GLU245 |
A | HOH2144 |
A | HOH2181 |
A | HOH2182 |
A | HOH2183 |
A | HOH2185 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A1337 |
Chain | Residue |
A | ASN196 |
A | HIS194 |
A | THR195 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K A1339 |
Chain | Residue |
A | ASP36 |
A | ASP37 |
A | ASP319 |
A | HOH2222 |
B | ARG26 |
B | LEU27 |
B | HOH2037 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B1336 |
Chain | Residue |
B | GLU245 |
B | HOH2145 |
B | HOH2146 |
B | HOH2149 |
B | HOH2189 |
B | HOH2191 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B1337 |
Chain | Residue |
B | THR195 |
B | ASN196 |
B | HOH2156 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K B1340 |
Chain | Residue |
A | ARG26 |
A | LEU27 |
A | HOH2039 |
A | HOH2040 |
B | ASP36 |
B | ASP37 |
B | ASP319 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PGE B1338 |
Chain | Residue |
A | PRO55 |
B | ASN298 |
B | TRP300 |
B | HOH2228 |
site_id | AC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PGE B1339 |
Chain | Residue |
A | ALA207 |
A | ALA209 |
A | ASP235 |
A | PRO236 |
A | ALA237 |
B | ARG29 |
B | SER304 |
B | GLU308 |
B | HOH2043 |
B | HOH2229 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PEG A1338 |
Chain | Residue |
A | GLY183 |
A | GLU187 |
A | ALA251 |
A | GLU252 |
A | HOH2227 |
B | TYR12 |
Functional Information from PROSITE/UniProt
site_id | PS00169 |
Number of Residues | 13 |
Details | D_ALA_DEHYDRATASE Delta-aminolevulinic acid dehydratase active site. GaDmVMVKPGmpY |
Chain | Residue | Details |
A | GLY253-TYR265 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Schiff-base intermediate with substrate => ECO:0000269|PubMed:12079382, ECO:0000269|PubMed:16819823 |
Chain | Residue | Details |
A | FHL205 | |
A | FHL260 | |
B | FHL205 | |
B | FHL260 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10356331, ECO:0000269|PubMed:12079382 |
Chain | Residue | Details |
A | ARG215 | |
B | TYR324 | |
A | LYS229 | |
A | GLU245 | |
A | SER286 | |
A | TYR324 | |
B | ARG215 | |
B | LYS229 | |
B | GLU245 | |
B | SER286 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 2 |
Details | M-CSA 230 |
Chain | Residue | Details |
A | FHL205 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, polar interaction, proton acceptor, proton donor |
A | FHL260 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, polar interaction, proton acceptor, proton donor |
site_id | MCSA2 |
Number of Residues | 2 |
Details | M-CSA 230 |
Chain | Residue | Details |
B | FHL205 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, polar interaction, proton acceptor, proton donor |
B | FHL260 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, polar interaction, proton acceptor, proton donor |