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2BZ5

Structure-based Discovery of a New Class of Hsp90 Inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0005524molecular_functionATP binding
A0006457biological_processprotein folding
A0016887molecular_functionATP hydrolysis activity
A0051082molecular_functionunfolded protein binding
A0140662molecular_functionATP-dependent protein folding chaperone
B0005524molecular_functionATP binding
B0006457biological_processprotein folding
B0016887molecular_functionATP hydrolysis activity
B0051082molecular_functionunfolded protein binding
B0140662molecular_functionATP-dependent protein folding chaperone
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE AB4 A1226
ChainResidue
AASN51
ALEU107
APHE138
ATHR184
AHOH2148
AHOH2284
AASP54
AALA55
ALYS58
AASP93
AILE96
AGLY97
AMET98
AASN106

site_idAC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE AB4 B1226
ChainResidue
BASN51
BASP54
BALA55
BLYS58
BASP93
BILE96
BGLY97
BMET98
BASN106
BTHR109
BGLY135
BPHE138
BTHR184
BVAL186
BHOH2061
BHOH2112
BHOH2140

Functional Information from PROSITE/UniProt
site_idPS00298
Number of Residues10
DetailsHSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE
ChainResidueDetails
ATYR38-GLU47

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING:
ChainResidueDetails
ASER52
ATHR94
ATYR139
BSER52
BTHR94
BTYR139

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ASER113
BSER113

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by PRKDC => ECO:0000269|PubMed:2507541
ChainResidueDetails
AGLN6
AGLN8
BGLN6
BGLN8

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P07901
ChainResidueDetails
AILE59
AGLN85
BILE59
BGLN85

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:2492519, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
AASP232
BASP232

218853

PDB entries from 2024-04-24

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