2BO8
DISSECTION OF MANNOSYLGLYCERATE SYNTHASE: AN ARCHETYPAL MANNOSYLTRANSFERASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016758 | molecular_function | hexosyltransferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051479 | biological_process | mannosylglycerate biosynthetic process |
| A | 0102921 | molecular_function | mannosylglycerate synthase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016758 | molecular_function | hexosyltransferase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051479 | biological_process | mannosylglycerate biosynthetic process |
| B | 0102921 | molecular_function | mannosylglycerate synthase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016758 | molecular_function | hexosyltransferase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051479 | biological_process | mannosylglycerate biosynthetic process |
| C | 0102921 | molecular_function | mannosylglycerate synthase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016758 | molecular_function | hexosyltransferase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051479 | biological_process | mannosylglycerate biosynthetic process |
| D | 0102921 | molecular_function | mannosylglycerate synthase activity |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016758 | molecular_function | hexosyltransferase activity |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0051479 | biological_process | mannosylglycerate biosynthetic process |
| E | 0102921 | molecular_function | mannosylglycerate synthase activity |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016758 | molecular_function | hexosyltransferase activity |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0051479 | biological_process | mannosylglycerate biosynthetic process |
| F | 0102921 | molecular_function | mannosylglycerate synthase activity |
| G | 0016740 | molecular_function | transferase activity |
| G | 0016758 | molecular_function | hexosyltransferase activity |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0051479 | biological_process | mannosylglycerate biosynthetic process |
| G | 0102921 | molecular_function | mannosylglycerate synthase activity |
| H | 0016740 | molecular_function | transferase activity |
| H | 0016758 | molecular_function | hexosyltransferase activity |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0051479 | biological_process | mannosylglycerate biosynthetic process |
| H | 0102921 | molecular_function | mannosylglycerate synthase activity |
| I | 0016740 | molecular_function | transferase activity |
| I | 0016758 | molecular_function | hexosyltransferase activity |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0051479 | biological_process | mannosylglycerate biosynthetic process |
| I | 0102921 | molecular_function | mannosylglycerate synthase activity |
| J | 0016740 | molecular_function | transferase activity |
| J | 0016758 | molecular_function | hexosyltransferase activity |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0051479 | biological_process | mannosylglycerate biosynthetic process |
| J | 0102921 | molecular_function | mannosylglycerate synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 500 |
| Chain | Residue |
| A | ASP102 |
| A | HIS217 |
| A | GDX400 |
| A | HOH2077 |
| A | HOH2078 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A1382 |
| Chain | Residue |
| A | ALA136 |
| A | THR139 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN B 500 |
| Chain | Residue |
| B | GDX400 |
| B | ASP102 |
| B | HIS217 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B1382 |
| Chain | Residue |
| B | ALA136 |
| B | THR139 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN C 500 |
| Chain | Residue |
| C | ASP102 |
| C | HIS217 |
| C | GDX400 |
| C | HOH2038 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C1382 |
| Chain | Residue |
| C | ALA136 |
| C | THR139 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN D 500 |
| Chain | Residue |
| D | ASP102 |
| D | HIS217 |
| D | GDX400 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D1382 |
| Chain | Residue |
| D | ALA136 |
| D | ILE138 |
| D | THR139 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN E 500 |
| Chain | Residue |
| E | ASP102 |
| E | HIS217 |
| E | GDX400 |
| E | HOH2034 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL E1382 |
| Chain | Residue |
| E | ALA136 |
| E | THR139 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN F 500 |
| Chain | Residue |
| F | ASP102 |
| F | HIS217 |
| F | GDX400 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL F1382 |
| Chain | Residue |
| F | ALA136 |
| F | ILE138 |
| F | THR139 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN G 500 |
| Chain | Residue |
| G | ASP102 |
| G | HIS217 |
| G | GDX400 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL G1382 |
| Chain | Residue |
| G | ALA136 |
| G | ILE138 |
| G | THR139 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN H 500 |
| Chain | Residue |
| H | ASP102 |
| H | HIS217 |
| H | GDX400 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL H1382 |
| Chain | Residue |
| H | ALA136 |
| H | ILE138 |
| H | THR139 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN I 500 |
| Chain | Residue |
| I | ASP102 |
| I | HIS217 |
| I | GDX400 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL I1382 |
| Chain | Residue |
| I | ALA136 |
| I | ILE138 |
| I | THR139 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN J 500 |
| Chain | Residue |
| J | ASP102 |
| J | HIS217 |
| J | GDX400 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL J1382 |
| Chain | Residue |
| J | ALA136 |
| J | ILE138 |
| J | THR139 |
| site_id | CC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE GDX A 400 |
| Chain | Residue |
| A | PRO7 |
| A | PHE8 |
| A | LYS9 |
| A | GLU11 |
| A | ILE35 |
| A | TYR37 |
| A | GLN66 |
| A | GLY75 |
| A | LYS76 |
| A | ASP100 |
| A | ALA101 |
| A | ASP102 |
| A | LEU163 |
| A | GLY165 |
| A | TRP189 |
| A | ASP192 |
| A | HIS217 |
| A | ARG218 |
| A | TYR220 |
| A | MET229 |
| A | MN500 |
| A | HOH2075 |
| A | HOH2076 |
| site_id | CC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDX B 400 |
| Chain | Residue |
| B | ASP192 |
| B | HIS217 |
| B | ARG218 |
| B | TYR220 |
| B | MET229 |
| B | MN500 |
| B | PRO7 |
| B | PHE8 |
| B | LYS9 |
| B | GLU11 |
| B | ILE35 |
| B | TYR37 |
| B | GLN66 |
| B | GLY75 |
| B | LYS76 |
| B | ASP100 |
| B | ALA101 |
| B | ASP102 |
| B | LEU163 |
| B | GLY164 |
| B | GLY165 |
| B | TRP189 |
| site_id | CC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDX C 400 |
| Chain | Residue |
| C | PRO7 |
| C | PHE8 |
| C | LYS9 |
| C | GLU11 |
| C | ILE35 |
| C | TYR37 |
| C | GLN66 |
| C | GLY75 |
| C | LYS76 |
| C | ASP100 |
| C | ALA101 |
| C | ASP102 |
| C | LEU163 |
| C | GLY164 |
| C | GLY165 |
| C | TRP189 |
| C | ASP192 |
| C | HIS217 |
| C | ARG218 |
| C | TYR220 |
| C | MET229 |
| C | MN500 |
| site_id | CC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDX D 400 |
| Chain | Residue |
| D | PRO7 |
| D | PHE8 |
| D | LYS9 |
| D | GLU11 |
| D | ILE35 |
| D | TYR37 |
| D | GLN66 |
| D | GLY75 |
| D | LYS76 |
| D | ASP100 |
| D | ALA101 |
| D | ASP102 |
| D | LEU163 |
| D | GLY164 |
| D | GLY165 |
| D | TRP189 |
| D | ASP192 |
| D | HIS217 |
| D | ARG218 |
| D | TYR220 |
| D | MET229 |
| D | MN500 |
| site_id | CC7 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE GDX E 400 |
| Chain | Residue |
| E | PRO7 |
| E | PHE8 |
| E | LYS9 |
| E | GLU11 |
| E | ILE35 |
| E | TYR37 |
| E | GLN66 |
| E | GLY75 |
| E | LYS76 |
| E | ASP100 |
| E | ALA101 |
| E | ASP102 |
| E | LEU163 |
| E | GLY164 |
| E | GLY165 |
| E | TRP189 |
| E | ASP192 |
| E | HIS217 |
| E | ARG218 |
| E | TYR220 |
| E | MET229 |
| E | MN500 |
| E | HOH2034 |
| site_id | CC8 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDX F 400 |
| Chain | Residue |
| F | PRO7 |
| F | PHE8 |
| F | LYS9 |
| F | GLU11 |
| F | ILE35 |
| F | TYR37 |
| F | GLN66 |
| F | GLY75 |
| F | LYS76 |
| F | ASP100 |
| F | ALA101 |
| F | ASP102 |
| F | LEU163 |
| F | GLY164 |
| F | GLY165 |
| F | TRP189 |
| F | ASP192 |
| F | HIS217 |
| F | ARG218 |
| F | TYR220 |
| F | MET229 |
| F | MN500 |
| site_id | CC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE GDX G 400 |
| Chain | Residue |
| G | PRO7 |
| G | PHE8 |
| G | LYS9 |
| G | GLU11 |
| G | ILE35 |
| G | TYR37 |
| G | GLN66 |
| G | GLY75 |
| G | LYS76 |
| G | ASP100 |
| G | ALA101 |
| G | ASP102 |
| G | LEU163 |
| G | GLY165 |
| G | TRP189 |
| G | ASP192 |
| G | HIS217 |
| G | ARG218 |
| G | TYR220 |
| G | MET229 |
| G | MN500 |
| site_id | DC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE GDX H 400 |
| Chain | Residue |
| H | PRO7 |
| H | PHE8 |
| H | LYS9 |
| H | GLU11 |
| H | ILE35 |
| H | TYR37 |
| H | GLN66 |
| H | GLY75 |
| H | LYS76 |
| H | ASP100 |
| H | ALA101 |
| H | ASP102 |
| H | LEU163 |
| H | GLY165 |
| H | TRP189 |
| H | ASP192 |
| H | HIS217 |
| H | ARG218 |
| H | TYR220 |
| H | MET229 |
| H | MN500 |
| site_id | DC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDX I 400 |
| Chain | Residue |
| I | PRO7 |
| I | PHE8 |
| I | LYS9 |
| I | GLU11 |
| I | ILE35 |
| I | TYR37 |
| I | GLN66 |
| I | GLY75 |
| I | LYS76 |
| I | ASP100 |
| I | ALA101 |
| I | ASP102 |
| I | LEU163 |
| I | GLY164 |
| I | GLY165 |
| I | TRP189 |
| I | ASP192 |
| I | HIS217 |
| I | ARG218 |
| I | TYR220 |
| I | MET229 |
| I | MN500 |
| site_id | DC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE GDX J 400 |
| Chain | Residue |
| J | PRO7 |
| J | PHE8 |
| J | LYS9 |
| J | GLU11 |
| J | ILE35 |
| J | TYR37 |
| J | GLN66 |
| J | GLY75 |
| J | LYS76 |
| J | ASP100 |
| J | ALA101 |
| J | ASP102 |
| J | LEU163 |
| J | GLY164 |
| J | GLY165 |
| J | TRP189 |
| J | ASP192 |
| J | LYS215 |
| J | HIS217 |
| J | ARG218 |
| J | TYR220 |
| J | MET229 |
| J | MN500 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 130 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | PRO7 | |
| A | ASP192 | |
| H | LEU163 | |
| H | ASP192 | |
| H | HIS217 | |
| H | ARG218 | |
| H | TYR220 | |
| I | PRO7 | |
| I | ILE35 | |
| I | GLN66 | |
| I | LYS76 | |
| I | ASP100 | |
| A | HIS217 | |
| I | ASP102 | |
| I | ARG131 | |
| I | ALA136 | |
| I | LEU163 | |
| I | ASP192 | |
| I | HIS217 | |
| I | ARG218 | |
| I | TYR220 | |
| J | PRO7 | |
| J | ILE35 | |
| A | ARG218 | |
| J | GLN66 | |
| J | LYS76 | |
| J | ASP100 | |
| J | ASP102 | |
| J | ARG131 | |
| J | ALA136 | |
| J | LEU163 | |
| J | ASP192 | |
| J | HIS217 | |
| J | ARG218 | |
| A | TYR220 | |
| J | TYR220 | |
| B | PRO7 | |
| B | ILE35 | |
| B | GLN66 | |
| B | LYS76 | |
| B | ASP100 | |
| B | ASP102 | |
| A | ILE35 | |
| B | ARG131 | |
| B | ALA136 | |
| B | LEU163 | |
| B | ASP192 | |
| B | HIS217 | |
| B | ARG218 | |
| B | TYR220 | |
| C | PRO7 | |
| C | ILE35 | |
| C | GLN66 | |
| A | GLN66 | |
| C | LYS76 | |
| C | ASP100 | |
| C | ASP102 | |
| C | ARG131 | |
| C | ALA136 | |
| C | LEU163 | |
| C | ASP192 | |
| C | HIS217 | |
| C | ARG218 | |
| C | TYR220 | |
| A | LYS76 | |
| D | PRO7 | |
| D | ILE35 | |
| D | GLN66 | |
| D | LYS76 | |
| D | ASP100 | |
| D | ASP102 | |
| D | ARG131 | |
| D | ALA136 | |
| D | LEU163 | |
| D | ASP192 | |
| A | ASP100 | |
| D | HIS217 | |
| D | ARG218 | |
| D | TYR220 | |
| E | PRO7 | |
| E | ILE35 | |
| E | GLN66 | |
| E | LYS76 | |
| E | ASP100 | |
| E | ASP102 | |
| E | ARG131 | |
| A | ASP102 | |
| E | ALA136 | |
| E | LEU163 | |
| E | ASP192 | |
| E | HIS217 | |
| E | ARG218 | |
| E | TYR220 | |
| F | PRO7 | |
| F | ILE35 | |
| F | GLN66 | |
| F | LYS76 | |
| A | ARG131 | |
| F | ASP100 | |
| F | ASP102 | |
| F | ARG131 | |
| F | ALA136 | |
| F | LEU163 | |
| F | ASP192 | |
| F | HIS217 | |
| F | ARG218 | |
| F | TYR220 | |
| G | PRO7 | |
| A | ALA136 | |
| G | ILE35 | |
| G | GLN66 | |
| G | LYS76 | |
| G | ASP100 | |
| G | ASP102 | |
| G | ARG131 | |
| G | ALA136 | |
| G | LEU163 | |
| G | ASP192 | |
| G | HIS217 | |
| A | LEU163 | |
| G | ARG218 | |
| G | TYR220 | |
| H | PRO7 | |
| H | ILE35 | |
| H | GLN66 | |
| H | LYS76 | |
| H | ASP100 | |
| H | ASP102 | |
| H | ARG131 | |
| H | ALA136 |
