Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NDP A1239 |
| Chain | Residue |
| A | CYS14 |
| A | ARG115 |
| A | SER116 |
| A | SER117 |
| A | LEU136 |
| A | SER137 |
| A | LYS138 |
| A | THR139 |
| A | ASP153 |
| A | SER154 |
| A | ILE173 |
| A | ALA15 |
| A | GLY174 |
| A | GLY175 |
| A | ALA176 |
| A | GLN177 |
| A | VAL178 |
| A | TYR179 |
| A | CP61240 |
| A | HOH2132 |
| A | HOH2139 |
| A | HOH2209 |
| A | LEU39 |
| A | HOH2260 |
| A | HOH2261 |
| A | HOH2262 |
| A | HOH2263 |
| A | HOH2264 |
| A | HOH2265 |
| A | GLY40 |
| A | ASN41 |
| A | GLY43 |
| A | THR44 |
| A | LEU45 |
| A | GLY114 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CP6 A1240 |
| Chain | Residue |
| A | ILE13 |
| A | CYS14 |
| A | ALA15 |
| A | ASP53 |
| A | PHE57 |
| A | SER117 |
| A | SER120 |
| A | ILE121 |
| A | ILE173 |
| A | TYR179 |
| A | THR194 |
| A | NDP1239 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 24 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GLGnkgtLPWkcnsvDmkyFssvT |
| Chain | Residue | Details |
| A | GLY38-THR61 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 11 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ILE13 | |
| A | TYR179 | |
| A | THR194 | |
| A | ALA15 | |
| A | GLY38 | |
| A | ASP53 | |
| A | ARG115 | |
| A | SER137 | |
| A | ASP153 | |
| A | ILE173 | |
| A | GLY174 | |
