Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2AL4

CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
F	0015276	molecular_function	ligand-gated monoatomic ion channel activity
F	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 821

Chain	Residue
A	GLU42
A	HIS46
B	GLU166

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN B 822

Chain	Residue
B	HIS23
B	GLU30

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN C 823

Chain	Residue
C	ASP65

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 824

Chain	Residue
B	GLN244
B	HOH825
B	GLU42
B	HIS46
B	LEU241

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN C 825

Chain	Residue
C	GLU42
C	HIS46

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 826

Chain	Residue
D	GLU42
D	HIS46
E	GLU166

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN E 827

Chain	Residue
E	HIS23
E	GLU30

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN F 828

Chain	Residue
F	ASP65

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN E 829

Chain	Residue
E	GLU42
E	HIS46
E	LEU241
E	GLN244
E	HOH832

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN F 830

Chain	Residue
F	GLU42
F	HIS46

site_id	BC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE CX6 C 801

Chain	Residue
A	PRO105
A	PHE106
A	MET107
A	SER108
A	SER217
A	LYS218
A	GLY219
A	ASN242
A	HOH952
C	PRO105
C	PHE106
C	MET107
C	SER108
C	SER217
C	LYS218
C	GLY219
C	ASN242
C	HOH851
C	HOH911
C	HOH934

site_id	BC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE CX6 E 802

Chain	Residue
B	PRO105
B	PHE106
B	MET107
B	SER108
B	SER217
B	LYS218
B	GLY219
B	ASN242
B	HOH967
E	PRO105
E	PHE106
E	MET107
E	SER108
E	SER217
E	LYS218
E	GLY219
E	ASN242
E	HOH830
E	HOH860
E	HOH975

site_id	BC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE CX6 F 803

Chain	Residue
D	PRO105
D	PHE106
D	MET107
D	SER108
D	SER217
D	LYS218
D	GLY219
D	ASN242
D	HOH778
F	PRO105
F	PHE106
F	MET107
F	SER108
F	SER217
F	LYS218
F	GLY219
F	ASN242
F	HOH515
F	HOH706
F	HOH775

site_id	BC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE QUS A 807

Chain	Residue
A	HOH835
A	HOH841
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	LEU192
A	GLU193
A	MET196
A	HOH822

site_id	BC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE QUS B 808

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	LEU192
B	GLU193
B	MET196
B	HOH829
B	HOH839
B	HOH850

site_id	BC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE QUS C 809

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	LEU138
C	GLY141
C	SER142
C	THR143
C	LEU192
C	GLU193
C	MET196
C	HOH829
C	HOH837
C	HOH865

site_id	BC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE QUS D 810

Chain	Residue
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	LEU138
D	GLY141
D	SER142
D	THR143
D	LEU192
D	GLU193
D	MET196
D	HOH392
D	HOH428
D	HOH455

site_id	BC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE QUS E 811

Chain	Residue
E	TYR61
E	PRO89
E	LEU90
E	THR91
E	ARG96
E	LEU138
E	GLY141
E	SER142
E	THR143
E	LEU192
E	GLU193
E	MET196
E	HOH836
E	HOH846
E	HOH857

site_id	CC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE QUS F 812

Chain	Residue
F	TYR61
F	PRO89
F	LEU90
F	THR91
F	ARG96
F	LEU138
F	GLY141
F	SER142
F	THR143
F	LEU192
F	GLU193
F	MET196
F	HOH417
F	HOH448
F	HOH557

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	TRANSMEM: Helical

Chain	Residue	Details
A	ALA134-VAL154
B	ASP207-GLY227
C	ALA134-VAL154
C	ASP207-GLY227
D	ALA134-VAL154
D	ASP207-GLY227
E	ALA134-VAL154
E	ASP207-GLY227
F	ALA134-VAL154
F	ASP207-GLY227
A	ASP207-GLY227
B	ALA134-VAL154

site_id	SWS_FT_FI2
Number of Residues	186
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
A	PHE155-VAL181
B	GLU201-CYS206
C	PHE155-VAL181
C	GLU201-CYS206
D	PHE155-VAL181
D	GLU201-CYS206
E	PHE155-VAL181
E	GLU201-CYS206
F	PHE155-VAL181
F	GLU201-CYS206
A	GLU201-CYS206
B	PHE155-VAL181

site_id	SWS_FT_FI3
Number of Residues	90
Details	INTRAMEM: Helical; Pore-forming

Chain	Residue	Details
A	ARG182-ASN197
C	ARG182-ASN197
D	ARG182-ASN197
E	ARG182-ASN197
F	ARG182-ASN197
B	ARG182-ASN197

site_id	SWS_FT_FI4
Number of Residues	12
Details	INTRAMEM:

Chain	Residue	Details
B	GLU198-ILE200
C	GLU198-ILE200
D	GLU198-ILE200
E	GLU198-ILE200
F	GLU198-ILE200
A	GLU198-ILE200

site_id	SWS_FT_FI5
Number of Residues	36
Details	BINDING: BINDING => ECO:0000269\|PubMed:11086992, ECO:0000269\|PubMed:16483599, ECO:0007744\|PDB:1FTJ, ECO:0007744\|PDB:2CMO

Chain	Residue	Details
D	PRO89
D	THR91
D	ARG96
D	SER142
D	THR143
D	GLU193
E	PRO89
E	THR91
E	ARG96
E	SER142
E	THR143
E	GLU193
F	PRO89
F	THR91
F	ARG96
F	SER142
F	THR143
F	GLU193
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

site_id	SWS_FT_FI6
Number of Residues	18
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
D	ARG64
D	ARG148
D	LYS240
E	ARG64
E	ARG148
E	LYS240
F	ARG64
F	ARG148
F	LYS240
C	ARG64
C	ARG148
C	LYS240
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240

site_id	SWS_FT_FI7
Number of Residues	6
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121
D	ILE121
E	ILE121
F	ILE121

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150
D	SER150
E	SER150
F	SER150

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184
D	SER184
E	SER184
F	SER184

site_id	SWS_FT_FI10
Number of Residues	6
Details	LIPID: S-palmitoyl cysteine => ECO:0000250

Chain	Residue	Details
A	ILE200
B	ILE200
E	ILE200
F	ILE200
C	ILE200
D	ILE200

site_id	SWS_FT_FI11
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
D	ASN3
E	ASN3
F	ASN3
B	ASN3
C	ASN3

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)