2A9V

Crystal structure of a putative gmp synthase subunit a protein (ta0944m) from thermoplasma acidophilum at 2.45 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003921	molecular_function	GMP synthase activity
A	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006177	biological_process	GMP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0016874	molecular_function	ligase activity
B	0003921	molecular_function	GMP synthase activity
B	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006177	biological_process	GMP biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0016874	molecular_function	ligase activity
C	0003921	molecular_function	GMP synthase activity
C	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0006177	biological_process	GMP biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0016874	molecular_function	ligase activity
D	0003921	molecular_function	GMP synthase activity
D	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006177	biological_process	GMP biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0016874	molecular_function	ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 501

Chain	Residue
B	GLU17
B	HOH546

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SCN A 201

Chain	Residue
A	LYS157
C	HIS99

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SCN D 201

Chain	Residue
B	SER146
B	HOH518
D	HIS111

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SCN B 502

Chain	Residue
D	SER108
D	SER145
D	SER146
D	ALA147
D	HOH238
B	HIS111
B	LEU142

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SCN C 201

Chain	Residue
C	LEU142
C	LYS157

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SCN C 202

Chain	Residue
B	HIS156
B	LYS157
B	THR158
B	ARG159
B	TYR162
C	TRP13

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 203

Chain	Residue
B	GLN12
B	TRP13
C	ASN114
C	HIS156
C	THR158
C	ARG159
C	TYR162
C	HOH221

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL D 202

Chain	Residue
D	VAL6
D	ASP8
D	GLN12
D	HIS15
D	GLU17
D	TRP18
D	SER49

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 202

Chain	Residue
A	ASN114
A	HIS156
A	ARG159
A	TYR162
A	HOH256
D	GLN12
D	TRP13
D	GOL204
D	HOH215

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 203

Chain	Residue
A	GLN12
A	TRP13
D	ASN114
D	HIS156
D	LYS157
D	THR158
D	ARG159
D	TYR162

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 204

Chain	Residue
C	GLY11
C	GLN12
C	THR14
C	ARG16
C	GLU17
C	GLU169

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 503

Chain	Residue
B	GLN150
D	ILE134
D	ASN135
D	LEU136
D	GLN150

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 204

Chain	Residue
A	GLU113
A	TYR155
A	GOL202
A	HOH205
D	ARG16
D	VAL170
D	GLU171
D	HIS172

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_01510

Chain	Residue	Details
A	CYS80
B	CYS80
C	CYS80
D	CYS80

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01510

Chain	Residue	Details
A	HIS167
A	GLU169
B	HIS167
B	GLU169
C	HIS167
C	GLU169
D	HIS167
D	GLU169

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