1ZGY

Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BRL A 503

Chain	Residue
A	HOH36
A	MET364
A	HIS449
A	LEU453
A	LEU469
A	TYR473
A	PHE282
A	GLY284
A	CYS285
A	SER289
A	HIS323
A	TYR327
A	LEU330
A	ILE341

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG

Chain	Residue	Details
A	GLN286
A	HIS323
A	HIS449
A	TYR473

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649

Chain	Residue	Details
A	LYS224

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