1YAG

STRUCTURE OF THE YEAST ACTIN-HUMAN GELSOLIN SEGMENT 1 COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000011	biological_process	vacuole inheritance
A	0000142	cellular_component	cellular bud neck contractile ring
A	0000166	molecular_function	nucleotide binding
A	0000785	cellular_component	chromatin
A	0000812	cellular_component	Swr1 complex
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005884	cellular_component	actin filament
A	0006281	biological_process	DNA repair
A	0006338	biological_process	chromatin remodeling
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006897	biological_process	endocytosis
A	0009306	biological_process	protein secretion
A	0016787	molecular_function	hydrolase activity
A	0030010	biological_process	establishment of cell polarity
A	0030476	biological_process	ascospore wall assembly
A	0030479	cellular_component	actin cortical patch
A	0031011	cellular_component	Ino80 complex
A	0032432	cellular_component	actin filament bundle
A	0035267	cellular_component	NuA4 histone acetyltransferase complex
A	0042802	molecular_function	identical protein binding
A	0043232	cellular_component	intracellular non-membrane-bounded organelle
A	1902404	biological_process	mitotic actomyosin contractile ring contraction
G	0051015	molecular_function	actin filament binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 376

Chain	Residue
A	ATP378
A	HOH386
A	HOH387
A	HOH394
A	HOH396

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 126

Chain	Residue
G	HOH151
G	HOH158
G	GLY41
G	ASP42
G	GLU73
G	VAL121

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 377

Chain	Residue
A	ARG62
A	ARG62
A	THR202
A	THR202
A	THR203
A	THR203
A	ALA204
A	ALA204

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site_id	AC4
Number of Residues	29
Details	BINDING SITE FOR RESIDUE ATP A 378

Chain	Residue
A	GLY13
A	SER14
A	GLY15
A	MET16
A	LYS18
A	GLY156
A	ASP157
A	GLY158
A	VAL159
A	GLY182
A	ARG210
A	LYS213
A	GLU214
A	GLY301
A	GLY302
A	THR303
A	MET305
A	PHE306
A	LYS336
A	MG376
A	HOH386
A	HOH387
A	HOH394
A	HOH397
A	HOH413
A	HOH416
A	HOH474
A	HOH504
A	HOH587

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Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

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site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

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site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApMNPksNR

Chain	Residue	Details
A	LEU104-ARG116

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:19666512, ECO:0007744|PDB:3FFK

Chain	Residue	Details
G	GLY41
G	ASP42
G	GLU73
G	ASP85
G	GLY90
G	ALA92
G	VAL121

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
G	LYS111

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by SRC; in vitro => ECO:0000269|PubMed:10210201

Chain	Residue	Details
G	TYR35

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