1XFC
The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006522 | biological_process | alanine metabolic process |
| A | 0008784 | molecular_function | alanine racemase activity |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0030632 | biological_process | D-alanine biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006522 | biological_process | alanine metabolic process |
| B | 0008784 | molecular_function | alanine racemase activity |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0030632 | biological_process | D-alanine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PLP A 390 |
| Chain | Residue |
| A | LYS42 |
| A | TYR364 |
| A | HOH426 |
| A | HOH543 |
| A | HOH551 |
| A | TYR46 |
| A | TRP88 |
| A | HIS172 |
| A | ASN212 |
| A | SER213 |
| A | ARG228 |
| A | GLY230 |
| A | ILE231 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PLP B 390 |
| Chain | Residue |
| B | LYS42 |
| B | TYR46 |
| B | TRP88 |
| B | HIS172 |
| B | SER213 |
| B | ARG228 |
| B | GLY230 |
| B | ILE231 |
| B | TYR364 |
| B | HOH429 |
| B | HOH537 |
Functional Information from PROSITE/UniProt
| site_id | PS00395 |
| Number of Residues | 11 |
| Details | ALANINE_RACEMASE Alanine racemase pyridoxal-phosphate attachment site. AVvKADGYGHG |
| Chain | Residue | Details |
| A | ALA39-GLY49 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor; specific for D-alanine => ECO:0000255|HAMAP-Rule:MF_01201 |
| Chain | Residue | Details |
| A | VAL40 | |
| B | VAL40 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor; specific for L-alanine => ECO:0000255|HAMAP-Rule:MF_01201 |
| Chain | Residue | Details |
| A | VAL269 | |
| B | VAL269 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01201 |
| Chain | Residue | Details |
| A | LEU138 | |
| A | ILE317 | |
| B | LEU138 | |
| B | ILE317 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:15683232 |
| Chain | Residue | Details |
| A | VAL40 | |
| B | VAL40 |
