Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1XFB

Human Brain Fructose 1,6-(bis)phosphate Aldolase (C isozyme)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004332	molecular_function	fructose-bisphosphate aldolase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0006000	biological_process	fructose metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0008092	molecular_function	cytoskeletal protein binding
A	0016829	molecular_function	lyase activity
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
A	0030855	biological_process	epithelial cell differentiation
A	0034774	cellular_component	secretory granule lumen
A	0070062	cellular_component	extracellular exosome
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0004332	molecular_function	fructose-bisphosphate aldolase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0006000	biological_process	fructose metabolic process
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0008092	molecular_function	cytoskeletal protein binding
B	0016829	molecular_function	lyase activity
B	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
B	0030855	biological_process	epithelial cell differentiation
B	0034774	cellular_component	secretory granule lumen
B	0070062	cellular_component	extracellular exosome
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0004332	molecular_function	fructose-bisphosphate aldolase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0006000	biological_process	fructose metabolic process
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0008092	molecular_function	cytoskeletal protein binding
C	0016829	molecular_function	lyase activity
C	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
C	0030855	biological_process	epithelial cell differentiation
C	0034774	cellular_component	secretory granule lumen
C	0070062	cellular_component	extracellular exosome
C	1904724	cellular_component	tertiary granule lumen
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0004332	molecular_function	fructose-bisphosphate aldolase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0006000	biological_process	fructose metabolic process
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0008092	molecular_function	cytoskeletal protein binding
D	0016829	molecular_function	lyase activity
D	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
D	0030855	biological_process	epithelial cell differentiation
D	0034774	cellular_component	secretory granule lumen
D	0070062	cellular_component	extracellular exosome
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0004332	molecular_function	fructose-bisphosphate aldolase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0006000	biological_process	fructose metabolic process
E	0006094	biological_process	gluconeogenesis
E	0006096	biological_process	glycolytic process
E	0008092	molecular_function	cytoskeletal protein binding
E	0016829	molecular_function	lyase activity
E	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
E	0030855	biological_process	epithelial cell differentiation
E	0034774	cellular_component	secretory granule lumen
E	0070062	cellular_component	extracellular exosome
E	1904724	cellular_component	tertiary granule lumen
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0004332	molecular_function	fructose-bisphosphate aldolase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0006000	biological_process	fructose metabolic process
F	0006094	biological_process	gluconeogenesis
F	0006096	biological_process	glycolytic process
F	0008092	molecular_function	cytoskeletal protein binding
F	0016829	molecular_function	lyase activity
F	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
F	0030855	biological_process	epithelial cell differentiation
F	0034774	cellular_component	secretory granule lumen
F	0070062	cellular_component	extracellular exosome
F	1904724	cellular_component	tertiary granule lumen
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0004332	molecular_function	fructose-bisphosphate aldolase activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0006000	biological_process	fructose metabolic process
G	0006094	biological_process	gluconeogenesis
G	0006096	biological_process	glycolytic process
G	0008092	molecular_function	cytoskeletal protein binding
G	0016829	molecular_function	lyase activity
G	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
G	0030855	biological_process	epithelial cell differentiation
G	0034774	cellular_component	secretory granule lumen
G	0070062	cellular_component	extracellular exosome
G	1904724	cellular_component	tertiary granule lumen
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0004332	molecular_function	fructose-bisphosphate aldolase activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0006000	biological_process	fructose metabolic process
H	0006094	biological_process	gluconeogenesis
H	0006096	biological_process	glycolytic process
H	0008092	molecular_function	cytoskeletal protein binding
H	0016829	molecular_function	lyase activity
H	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
H	0030855	biological_process	epithelial cell differentiation
H	0034774	cellular_component	secretory granule lumen
H	0070062	cellular_component	extracellular exosome
H	1904724	cellular_component	tertiary granule lumen
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0004332	molecular_function	fructose-bisphosphate aldolase activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0006000	biological_process	fructose metabolic process
I	0006094	biological_process	gluconeogenesis
I	0006096	biological_process	glycolytic process
I	0008092	molecular_function	cytoskeletal protein binding
I	0016829	molecular_function	lyase activity
I	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
I	0030855	biological_process	epithelial cell differentiation
I	0034774	cellular_component	secretory granule lumen
I	0070062	cellular_component	extracellular exosome
I	1904724	cellular_component	tertiary granule lumen
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0004332	molecular_function	fructose-bisphosphate aldolase activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0006000	biological_process	fructose metabolic process
J	0006094	biological_process	gluconeogenesis
J	0006096	biological_process	glycolytic process
J	0008092	molecular_function	cytoskeletal protein binding
J	0016829	molecular_function	lyase activity
J	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
J	0030855	biological_process	epithelial cell differentiation
J	0034774	cellular_component	secretory granule lumen
J	0070062	cellular_component	extracellular exosome
J	1904724	cellular_component	tertiary granule lumen
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0004332	molecular_function	fructose-bisphosphate aldolase activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0006000	biological_process	fructose metabolic process
K	0006094	biological_process	gluconeogenesis
K	0006096	biological_process	glycolytic process
K	0008092	molecular_function	cytoskeletal protein binding
K	0016829	molecular_function	lyase activity
K	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
K	0030855	biological_process	epithelial cell differentiation
K	0034774	cellular_component	secretory granule lumen
K	0070062	cellular_component	extracellular exosome
K	1904724	cellular_component	tertiary granule lumen
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0004332	molecular_function	fructose-bisphosphate aldolase activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0006000	biological_process	fructose metabolic process
L	0006094	biological_process	gluconeogenesis
L	0006096	biological_process	glycolytic process
L	0008092	molecular_function	cytoskeletal protein binding
L	0016829	molecular_function	lyase activity
L	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
L	0030855	biological_process	epithelial cell differentiation
L	0034774	cellular_component	secretory granule lumen
L	0070062	cellular_component	extracellular exosome
L	1904724	cellular_component	tertiary granule lumen
L	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00158
Number of Residues	11
Details	ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VyLEGtLLKPN

Chain	Residue	Details
A	VAL222-ASN232

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	GLU188
J	GLU188
K	GLU188
L	GLU188
B	GLU188
C	GLU188
D	GLU188
E	GLU188
F	GLU188
G	GLU188
H	GLU188
I	GLU188

site_id	SWS_FT_FI2
Number of Residues	12
Details	ACT_SITE: Schiff-base intermediate with dihydroxyacetone-P

Chain	Residue	Details
A	LYS230
J	LYS230
K	LYS230
L	LYS230
B	LYS230
C	LYS230
D	LYS230
E	LYS230
F	LYS230
G	LYS230
H	LYS230
I	LYS230

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
A	ARG56
E	LYS147
F	ARG56
F	LYS147
G	ARG56
G	LYS147
H	ARG56
H	LYS147
I	ARG56
I	LYS147
J	ARG56
A	LYS147
J	LYS147
K	ARG56
K	LYS147
L	ARG56
L	LYS147
B	ARG56
B	LYS147
C	ARG56
C	LYS147
D	ARG56
D	LYS147
E	ARG56

site_id	SWS_FT_FI4
Number of Residues	12
Details	SITE: Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

Chain	Residue	Details
A	TYR364
J	TYR364
K	TYR364
L	TYR364
B	TYR364
C	TYR364
D	TYR364
E	TYR364
F	TYR364
G	TYR364
H	TYR364
I	TYR364

site_id	SWS_FT_FI5
Number of Residues	12
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P05065

Chain	Residue	Details
A	TYR5
J	TYR5
K	TYR5
L	TYR5
B	TYR5
C	TYR5
D	TYR5
E	TYR5
F	TYR5
G	TYR5
H	TYR5
I	TYR5

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER36
J	SER36
K	SER36
L	SER36
B	SER36
C	SER36
D	SER36
E	SER36
F	SER36
G	SER36
H	SER36
I	SER36

site_id	SWS_FT_FI7
Number of Residues	24
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER39
E	SER45
F	SER39
F	SER45
G	SER39
G	SER45
H	SER39
H	SER45
I	SER39
I	SER45
J	SER39
A	SER45
J	SER45
K	SER39
K	SER45
L	SER39
L	SER45
B	SER39
B	SER45
C	SER39
C	SER45
D	SER39
D	SER45
E	SER39

site_id	SWS_FT_FI8
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19413330

Chain	Residue	Details
A	LYS111
J	LYS111
K	LYS111
L	LYS111
B	LYS111
C	LYS111
D	LYS111
E	LYS111
F	LYS111
G	LYS111
H	LYS111
I	LYS111

site_id	SWS_FT_FI9
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P05065

Chain	Residue	Details
A	SER132
J	SER132
K	SER132
L	SER132
B	SER132
C	SER132
D	SER132
E	SER132
F	SER132
G	SER132
H	SER132
I	SER132

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)