1WPX
Crystal structure of carboxypeptidase Y inhibitor complexed with the cognate proteinase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004185 | molecular_function | serine-type carboxypeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0000328 | cellular_component | fungal-type vacuole lumen |
| B | 0000329 | cellular_component | fungal-type vacuole membrane |
| B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0030162 | biological_process | regulation of proteolysis |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| B | 0046578 | biological_process | regulation of Ras protein signal transduction |
Functional Information from PROSITE/UniProt
| site_id | PS00131 |
| Number of Residues | 8 |
| Details | CARBOXYPEPT_SER_SER Serine carboxypeptidases, serine active site. IaGESYAG |
| Chain | Residue | Details |
| A | ILE142-GLY149 |
| site_id | PS00560 |
| Number of Residues | 18 |
| Details | CARBOXYPEPT_SER_HIS Serine carboxypeptidases, histidine active site. FtyLrVfNGGHmVPfdvP |
| Chain | Residue | Details |
| A | PHE387-PRO404 |
| site_id | PS01220 |
| Number of Residues | 23 |
| Details | PBP Phosphatidylethanolamine-binding protein family signature. FtLVmTDPDaPSktdhkwsefcH |
| Chain | Residue | Details |
| B | PHE589-HIS611 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:12473200 |
| Chain | Residue | Details |
| B | MET501 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:7727362 |
| Chain | Residue | Details |
| A | ASP338 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:2639680, ECO:0000305|PubMed:7727362 |
| Chain | Residue | Details |
| A | HIS397 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|DOI:10.1007/BF02907496 |
| Chain | Residue | Details |
| A | CYS341 | |
| A | MET398 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000269|PubMed:28189789 |
| Chain | Residue | Details |
| A | ASN13 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000269|PubMed:15713484, ECO:0000269|PubMed:28189789, ECO:0000269|PubMed:7727362 |
| Chain | Residue | Details |
| A | ASN87 | |
| A | ASN168 | |
| A | ASN368 |
