1WMA

Crystal structure of human CBR1 in complex with Hydroxy-PP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004090	molecular_function	carbonyl reductase (NADPH) activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
A	0008211	biological_process	glucocorticoid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
A	0019371	biological_process	cyclooxygenase pathway
A	0030855	biological_process	epithelial cell differentiation
A	0042373	biological_process	vitamin K metabolic process
A	0047020	molecular_function	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
A	0047021	molecular_function	15-hydroxyprostaglandin dehydrogenase (NADP+) activity
A	0050221	molecular_function	prostaglandin-E2 9-reductase activity
A	0070062	cellular_component	extracellular exosome
A	1903561	cellular_component	extracellular vesicle
A	2000379	biological_process	positive regulation of reactive oxygen species metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 300

Chain	Residue
A	ARG57
A	PHE58
A	HOH542
A	HOH639

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	SO4305
A	HOH424
A	HOH458
A	HOH553
A	HOH559
A	PHE102
A	SER190
A	SER191
A	ALA192
A	TYR193

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	LYS216
A	GLY217
A	ASP218
A	LYS219
A	HOH506
A	HOH511
A	HOH761

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	ASP64
A	LYS111
A	THR163
A	ARG209
A	LYS210
A	GLU213
A	HOH446
A	HOH460
A	HOH677

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	ARG41
A	ARG118
A	HOH571
A	HOH656
A	HOH675
A	HOH684

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 305

Chain	Residue
A	VAL96
A	ALA97
A	ARG272
A	SO4301
A	HOH502
A	HOH553
A	HOH559
A	HOH576

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 306

Chain	Residue
A	SER2
A	GLY3
A	GLN47
A	GLN50
A	LYS129
A	HOH742

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AB3 A 307

Chain	Residue
A	SER139
A	MET141
A	TYR193
A	GLY228
A	TRP229
A	AB3308
A	NDP309
A	PE5310
A	HOH479

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE AB3 A 308

Chain	Residue
A	ARG22
A	ARG26
A	ILE140
A	ARG144
A	GLU244
A	AB3307
A	PE5310
A	HOH484
A	HOH607
A	HOH642

---

site_id	BC1
Number of Residues	39
Details	BINDING SITE FOR RESIDUE NDP A 309

Chain	Residue
A	HOH430
A	HOH449
A	HOH481
A	HOH523
A	HOH549
A	HOH661
A	HOH664
A	HOH666
A	HOH721
A	GLY11
A	ASN13
A	LYS14
A	GLY15
A	ILE16
A	ARG37
A	LEU61
A	ASP62
A	ILE63
A	ASP64
A	ASN89
A	ALA90
A	GLY91
A	ILE92
A	VAL137
A	SER138
A	TYR193
A	LYS197
A	PRO227
A	GLY228
A	TRP229
A	VAL230
A	THR232
A	ASP233
A	MET234
A	ALA235
A	AB3307
A	HOH402
A	HOH406
A	HOH407

---

site_id	BC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PE5 A 310

Chain	Residue
A	ASP23
A	ALA93
A	MET141
A	ARG144
A	MET234
A	GLU248
A	TYR252
A	AB3307
A	AB3308
A	HOH416
A	HOH423
A	HOH466
A	HOH495

---

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE P33 A 311

Chain	Residue
A	ALA93
A	THR122
A	LEU125
A	HIS207
A	LYS210
A	LEU211
A	GLN214
A	HOH623
A	HOH697
A	HOH730

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. KgvhqkegwpSsaYGVTKIGVtVLSrIHA

Chain	Residue	Details
A	LYS180-ALA208

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	GLY194

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18826943

Chain	Residue	Details
A	THR10
A	ILE63
A	ALA90
A	GLY194
A	ARG231

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	LYS95
A	ALA106
A	ILE140
A	TYR193

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P47727

Chain	Residue	Details
A	SER2

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P48758

Chain	Residue	Details
A	GLY30

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-1-carboxyethyl lysine => ECO:0000269|PubMed:8421682

Chain	Residue	Details
A	ALA239

---