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1W0G

Crystal structure of human cytochrome P450 3A4

Functional Information from GO Data
ChainGOidnamespacecontents
A0002933biological_processlipid hydroxylation
A0004497molecular_functionmonooxygenase activity
A0005496molecular_functionsteroid binding
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006694biological_processsteroid biosynthetic process
A0006706biological_processsteroid catabolic process
A0006805biological_processxenobiotic metabolic process
A0008202biological_processsteroid metabolic process
A0008203biological_processcholesterol metabolic process
A0008209biological_processandrogen metabolic process
A0008210biological_processestrogen metabolic process
A0008395molecular_functionsteroid hydroxylase activity
A0008401molecular_functionretinoic acid 4-hydroxylase activity
A0009822biological_processalkaloid catabolic process
A0016020cellular_componentmembrane
A0016098biological_processmonoterpenoid metabolic process
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A0019825molecular_functionoxygen binding
A0019899molecular_functionenzyme binding
A0020037molecular_functionheme binding
A0030343molecular_functionvitamin D3 25-hydroxylase activity
A0034875molecular_functioncaffeine oxidase activity
A0036378biological_processcalcitriol biosynthetic process from calciol
A0042178biological_processxenobiotic catabolic process
A0042359biological_processvitamin D metabolic process
A0042369biological_processvitamin D catabolic process
A0042572biological_processretinol metabolic process
A0042573biological_processretinoic acid metabolic process
A0042759biological_processlong-chain fatty acid biosynthetic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0046222biological_processaflatoxin metabolic process
A0046872molecular_functionmetal ion binding
A0050591molecular_functionquinine 3-monooxygenase activity
A0050649molecular_functiontestosterone 6-beta-hydroxylase activity
A0062181molecular_function1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity
A0062187molecular_functionanandamide 8,9 epoxidase activity
A0062188molecular_functionanandamide 11,12 epoxidase activity
A0062189molecular_functionanandamide 14,15 epoxidase activity
A0070330molecular_functionaromatase activity
A0070576molecular_functionvitamin D 24-hydroxylase activity
A0070989biological_processoxidative demethylation
A0101020molecular_functionestrogen 16-alpha-hydroxylase activity
A0101021molecular_functionestrogen 2-hydroxylase activity
A0102320molecular_function1,8-cineole 2-exo-monooxygenase activity
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE HEM A1501
ChainResidue
AARG105
APRO434
APHE435
AGLY436
ASER437
AARG440
AASN441
ACYS442
AILE443
AALA448
AMYT1499
AILE118
ATRP126
AARG130
APHE137
APHE302
AALA305
ATHR309
AARG375

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MYT A1499
ChainResidue
ASER119
AALA305
ATHR309
AALA370
AHEM1501

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGsGPRNCIG
ChainResidueDetails
APHE435-GLY444

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: axial binding residue => ECO:0007744|PDB:1TQN, ECO:0007744|PDB:1W0G
ChainResidueDetails
AILE443

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1akd
ChainResidueDetails
ATHR309
AGLU308

219140

PDB entries from 2024-05-01

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