1VHC

Crystal structure of a putative KHG/KDPG aldolase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
A	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
A	0016829	molecular_function	lyase activity
A	0106009	molecular_function	(4S)-4-hydroxy-2-oxoglutarate aldolase activity
B	0005737	cellular_component	cytoplasm
B	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
B	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
B	0016829	molecular_function	lyase activity
B	0106009	molecular_function	(4S)-4-hydroxy-2-oxoglutarate aldolase activity
C	0005737	cellular_component	cytoplasm
C	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
C	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
C	0016829	molecular_function	lyase activity
C	0106009	molecular_function	(4S)-4-hydroxy-2-oxoglutarate aldolase activity
D	0005737	cellular_component	cytoplasm
D	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
D	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
D	0016829	molecular_function	lyase activity
D	0106009	molecular_function	(4S)-4-hydroxy-2-oxoglutarate aldolase activity
E	0005737	cellular_component	cytoplasm
E	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
E	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
E	0016829	molecular_function	lyase activity
E	0106009	molecular_function	(4S)-4-hydroxy-2-oxoglutarate aldolase activity
F	0005737	cellular_component	cytoplasm
F	0008675	molecular_function	2-dehydro-3-deoxy-phosphogluconate aldolase activity
F	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
F	0016829	molecular_function	lyase activity
F	0106009	molecular_function	(4S)-4-hydroxy-2-oxoglutarate aldolase activity

Functional Information from PROSITE/UniProt

site_id	PS00159
Number of Residues	10
Details	ALDOLASE_KDPG_KHG_1 KDPG and KHG aldolases active site. GLsvaEITFR

Chain	Residue	Details
A	GLY40-ARG49

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site_id	PS00160
Number of Residues	14
Details	ALDOLASE_KDPG_KHG_2 KDPG and KHG aldolases Schiff-base forming residue. GisaVKFFPAeasG

Chain	Residue	Details
A	GLY128-GLY141

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10118

Chain	Residue	Details
A	GLU45
A	ARG49
B	GLU45
B	ARG49
C	GLU45
C	ARG49
D	GLU45
D	ARG49
E	GLU45
E	ARG49
F	GLU45
F	ARG49

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site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Schiff-base intermediate with KHG or pyruvate => ECO:0000255|PROSITE-ProRule:PRU10118

Chain	Residue	Details
A	LYS133
B	LYS133
C	LYS133
D	LYS133
E	LYS133
F	LYS133

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