1VFN
PURINE NUCLEOSIDE PHOSPHORYLASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0047975 | molecular_function | guanosine phosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 301 |
| Chain | Residue |
| A | HOH335 |
| A | HOH345 |
| A | HOH346 |
| A | HOH347 |
| A | HOH348 |
| A | HOH349 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 434 |
| Chain | Residue |
| A | HIS20 |
| A | HIS20 |
| A | HIS20 |
| A | HOH433 |
| A | HOH433 |
| A | HOH433 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE HPA A 300 |
| Chain | Residue |
| A | ALA116 |
| A | ALA117 |
| A | GLY118 |
| A | PHE200 |
| A | GLU201 |
| A | VAL217 |
| A | GLY218 |
| A | THR242 |
| A | ASN243 |
| A | LYS244 |
| A | HOH302 |
| A | HOH342 |
| site_id | BAS |
| Number of Residues | 4 |
| Details | BASE BINDING SITE. |
| Chain | Residue |
| A | GLU201 |
| A | ASN243 |
| A | HOH302 |
| A | HOH342 |
| site_id | PRE |
| Number of Residues | 11 |
| Details | PHOSPHATE BINDING SITE. |
| Chain | Residue |
| A | SER220 |
| A | HOH342 |
| A | HOH425 |
| A | HOH418 |
| A | HOH328 |
| A | HOH389 |
| A | TYR88 |
| A | ARG84 |
| A | ALA116 |
| A | PRO92 |
| A | MET219 |
Functional Information from PROSITE/UniProt
| site_id | PS01240 |
| Number of Residues | 42 |
| Details | PNP_MTAP_2 Purine and other phosphorylases family 2 signature. VmmqGrfHmYegypFwkvTfpVrVfrllGvet.LVvtNAaGGL |
| Chain | Residue | Details |
| A | VAL79-LEU120 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP |
| Chain | Residue | Details |
| A | SER33 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP |
| Chain | Residue | Details |
| A | HIS64 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP |
| Chain | Residue | Details |
| A | ARG84 | |
| A | ALA116 | |
| A | SER220 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T |
| Chain | Residue | Details |
| A | MET219 | |
| A | HIS257 | |
| A | TYR88 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0000305|PubMed:9020983, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1VFN |
| Chain | Residue | Details |
| A | GLU201 | |
| A | ASN243 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Important for substrate specificity => ECO:0000250|UniProtKB:P00491 |
| Chain | Residue | Details |
| A | ASN243 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00491 |
| Chain | Residue | Details |
| A | SER251 |
