Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1UW6

X-ray structure of acetylcholine binding protein (AChBP) in complex with nicotine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport
K	0004888	molecular_function	transmembrane signaling receptor activity
K	0005216	molecular_function	monoatomic ion channel activity
K	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
K	0006811	biological_process	monoatomic ion transport
K	0016020	cellular_component	membrane
K	0034220	biological_process	monoatomic ion transmembrane transport
L	0004888	molecular_function	transmembrane signaling receptor activity
L	0005216	molecular_function	monoatomic ion channel activity
L	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
L	0006811	biological_process	monoatomic ion transport
L	0016020	cellular_component	membrane
L	0034220	biological_process	monoatomic ion transmembrane transport
M	0004888	molecular_function	transmembrane signaling receptor activity
M	0005216	molecular_function	monoatomic ion channel activity
M	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
M	0006811	biological_process	monoatomic ion transport
M	0016020	cellular_component	membrane
M	0034220	biological_process	monoatomic ion transmembrane transport
N	0004888	molecular_function	transmembrane signaling receptor activity
N	0005216	molecular_function	monoatomic ion channel activity
N	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
N	0006811	biological_process	monoatomic ion transport
N	0016020	cellular_component	membrane
N	0034220	biological_process	monoatomic ion transmembrane transport
O	0004888	molecular_function	transmembrane signaling receptor activity
O	0005216	molecular_function	monoatomic ion channel activity
O	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
O	0006811	biological_process	monoatomic ion transport
O	0016020	cellular_component	membrane
O	0034220	biological_process	monoatomic ion transmembrane transport
P	0004888	molecular_function	transmembrane signaling receptor activity
P	0005216	molecular_function	monoatomic ion channel activity
P	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
P	0006811	biological_process	monoatomic ion transport
P	0016020	cellular_component	membrane
P	0034220	biological_process	monoatomic ion transmembrane transport
Q	0004888	molecular_function	transmembrane signaling receptor activity
Q	0005216	molecular_function	monoatomic ion channel activity
Q	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
Q	0006811	biological_process	monoatomic ion transport
Q	0016020	cellular_component	membrane
Q	0034220	biological_process	monoatomic ion transmembrane transport
R	0004888	molecular_function	transmembrane signaling receptor activity
R	0005216	molecular_function	monoatomic ion channel activity
R	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
R	0006811	biological_process	monoatomic ion transport
R	0016020	cellular_component	membrane
R	0034220	biological_process	monoatomic ion transmembrane transport
S	0004888	molecular_function	transmembrane signaling receptor activity
S	0005216	molecular_function	monoatomic ion channel activity
S	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
S	0006811	biological_process	monoatomic ion transport
S	0016020	cellular_component	membrane
S	0034220	biological_process	monoatomic ion transmembrane transport
T	0004888	molecular_function	transmembrane signaling receptor activity
T	0005216	molecular_function	monoatomic ion channel activity
T	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
T	0006811	biological_process	monoatomic ion transport
T	0016020	cellular_component	membrane
T	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NCT A1208

Chain	Residue
A	TYR89
A	TRP143
A	TYR192
A	HOH2090
B	TRP53
B	MET114

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NCT B1206

Chain	Residue
B	TYR192
C	LEU112
C	HOH2052
B	TYR89
B	TRP143
B	CYS188

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NCT C1206

Chain	Residue
C	TYR89
C	TRP143
C	CYS188
C	TYR192
C	HOH2081
D	TRP53
D	MET114

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NCT D1208

Chain	Residue
D	TYR89
D	TRP143
D	THR144
D	TYR192
E	LEU112
E	HOH2041

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NCT E1206

Chain	Residue
A	TRP53
A	LEU112
E	TYR89
E	TRP143
E	CYS188
E	TYR192
E	HOH2063

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NCT F1208

Chain	Residue
F	TYR89
F	TRP143
F	CYS188
F	TYR192
G	TRP53
G	HOH2041

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NCT G1206

Chain	Residue
G	TYR89
G	TRP143
G	CYS188
G	TYR192
H	TRP53

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NCT H1206

Chain	Residue
H	TYR89
H	TRP143
H	TYR185
H	CYS188
H	TYR192
I	LEU112
I	MET114
I	HOH2040

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NCT I1206

Chain	Residue
I	TYR89
I	TRP143
I	CYS188
I	TYR192
I	HOH2071
J	TRP53
J	LEU112
J	MET114

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NCT J1206

Chain	Residue
F	LEU112
F	MET114
J	TYR89
J	TRP143
J	THR144
J	TYR192
J	HOH2070

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NCT K1206

Chain	Residue
K	TYR89
K	TRP143
K	TYR192
K	HOH2055
L	TRP53
L	MET114

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NCT L1206

Chain	Residue
L	TYR89
L	TRP143
L	CYS187
L	TYR192
L	HOH2041
M	TRP53
M	MET114

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NCT M1208

Chain	Residue
M	TYR89
M	TRP143
M	TYR185
M	CYS187
M	CYS188
M	TYR192
N	LEU112
N	MET114
N	HOH2043

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NCT N1208

Chain	Residue
N	TYR89
N	TRP143
N	CYS188
N	TYR192
O	TRP53
O	LEU112
O	MET114
O	HOH2038

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NCT O1206

Chain	Residue
O	TYR192
O	HOH2071
O	TYR89
O	TRP143
O	THR144

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NCT P1206

Chain	Residue
P	TYR89
P	TRP143
P	TYR192
P	HOH2095
Q	TRP53
Q	LEU112
Q	MET114

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NCT Q1206

Chain	Residue
Q	TYR89
Q	TRP143
Q	THR144
Q	CYS188
Q	TYR192
Q	HOH2075

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NCT R1208

Chain	Residue
R	TYR89
R	TRP143
R	TYR192
S	TRP53
S	LEU112
S	HOH2038

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NCT S1206

Chain	Residue
S	TYR89
S	TRP143
S	CYS188
S	TYR192
S	HOH2068
T	LEU112

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NCT T1208

Chain	Residue
P	TRP53
P	LEU112
P	HOH2060
T	TYR89
T	TRP143
T	TYR192

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN66
J	ASN66
K	ASN66
L	ASN66
M	ASN66
N	ASN66
O	ASN66
P	ASN66
Q	ASN66
R	ASN66
S	ASN66
B	ASN66
T	ASN66
C	ASN66
D	ASN66
E	ASN66
F	ASN66
G	ASN66
H	ASN66
I	ASN66

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)