1URM

HUMAN PEROXIREDOXIN 5, C47S MUTANT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016491	molecular_function	oxidoreductase activity
A	0034599	biological_process	cellular response to oxidative stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A1162

Chain	Residue
A	LYS63
A	LYS93
A	SER118
A	HOH2189

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A1163

Chain	Residue
A	ARG86
A	LYS89
A	ALA90
A	GLU91

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A1164

Chain	Residue
A	PRO155
A	HOH2022
A	HOH2123
A	HOH2132
A	GLY54

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE BEZ A 201

Chain	Residue
A	PRO40
A	THR44
A	PRO45
A	GLY46
A	SER47
A	LYS63
A	ALA64
A	PHE120
A	ARG127
A	THR147
A	HOH2145

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305|PubMed:10751410, ECO:0000305|PubMed:20643143

Chain	Residue	Details
A	SER47

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P99029

Chain	Residue	Details
A	LYS22

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99029

Chain	Residue	Details
A	LYS30

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P99029

Chain	Residue	Details
A	LYS63

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9R063

Chain	Residue	Details
A	SER118

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P99029

Chain	Residue	Details
A	SER129

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:31740833

Chain	Residue	Details
A	SER47

---