1U9Z

Crystal Structure of Phosphoribosyl Diphosphate Synthase Complexed with AMP and Ribose 5-Phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0002189	cellular_component	ribose phosphate diphosphokinase complex
A	0004749	molecular_function	ribose phosphate diphosphokinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0002189	cellular_component	ribose phosphate diphosphokinase complex
B	0004749	molecular_function	ribose phosphate diphosphokinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0002189	cellular_component	ribose phosphate diphosphokinase complex
C	0004749	molecular_function	ribose phosphate diphosphokinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0016301	molecular_function	kinase activity
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0002189	cellular_component	ribose phosphate diphosphokinase complex
D	0004749	molecular_function	ribose phosphate diphosphokinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
D	0009165	biological_process	nucleotide biosynthetic process
D	0016301	molecular_function	kinase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE R5P A 5301

Chain	Residue
A	ASP163
A	HOH5445
A	ASP212
A	ILE214
A	ILE215
A	SER216
A	THR217
A	GLY218
A	GLY219
A	THR220

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE R5P B 6301

Chain	Residue
B	ASP163
B	ASP212
B	ILE214
B	ILE215
B	SER216
B	THR217
B	GLY218
B	GLY219
B	THR220
B	HOH6445

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE R5P C 7301

Chain	Residue
C	ASP163
C	ASP212
C	ILE214
C	ILE215
C	SER216
C	THR217
C	GLY218
C	GLY219
C	THR220
C	HOH7445

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE R5P D 8301

Chain	Residue
D	ASP163
D	ASP212
D	ILE214
D	SER216
D	THR217
D	GLY218
D	GLY219
D	THR220
D	HOH8445

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE AMP B 5302

Chain	Residue
A	ARG92
A	GLN93
A	ASP94
A	PHE97
A	HIS125
B	PHE32
B	ASP34
B	GLU36
B	HOH5424
B	HOH5437

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE AMP B 6302

Chain	Residue
A	PHE32
A	ASP34
A	GLU36
B	ARG92
B	GLN93
B	ASP94
B	PHE97
B	HIS125
B	HOH6424
B	HOH6437

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AMP D 7302

Chain	Residue
C	ARG92
C	GLN93
C	PHE97
C	HIS125
D	PHE32
D	ASP34
D	GLU36
D	HOH7424
D	HOH7437

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AMP C 8302

Chain	Residue
C	PHE32
C	ASP34
C	GLU36
C	HOH8424
C	HOH8437
D	ARG92
D	GLN93
D	PHE97
D	HIS125

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00583

Chain	Residue	Details
A	LYS186
B	LYS186
C	LYS186
D	LYS186

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00583, ECO:0000269|PubMed:16288921, ECO:0007744|PDB:1U9Z

Chain	Residue	Details
B	ASP212
B	SER216
C	ASP34
C	ASP212
C	SER216
D	ASP34
D	ASP212
D	SER216
A	ASP34
A	ASP212
A	SER216
B	ASP34

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00583, ECO:0000305|PubMed:16288921, ECO:0007744|PDB:1U9Z

Chain	Residue	Details
A	ARG92
B	ARG92
C	ARG92
D	ARG92

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00583

Chain	Residue	Details
B	ASP163
B	ARG188
C	HIS125
C	ASP163
C	ARG188
D	HIS125
D	ASP163
D	ARG188
A	HIS125
A	ASP163
A	ARG188
B	HIS125

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