1TED

Crystal structure of a type III polyketide synthase PKS18 from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0009715	biological_process	chalcone biosynthetic process
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0030639	biological_process	polyketide biosynthetic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0009058	biological_process	biosynthetic process
B	0009715	biological_process	chalcone biosynthetic process
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0030639	biological_process	polyketide biosynthetic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0009058	biological_process	biosynthetic process
C	0009715	biological_process	chalcone biosynthetic process
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0030639	biological_process	polyketide biosynthetic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0009058	biological_process	biosynthetic process
D	0009715	biological_process	chalcone biosynthetic process
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0030639	biological_process	polyketide biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MYR A 3045

Chain	Residue
A	MET83
A	PHE224
A	PRO87
A	SER143
A	THR144
A	CYS205
A	SER206
A	PHE211
A	ILE220
A	HIS221

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MYR B 3046

Chain	Residue
B	MET83
B	PRO87
B	SER143
B	CYS205
B	ALA209
B	PHE211
B	HIS221
B	PHE224
B	LEU266
B	ILE273
B	THR274
B	CYS275

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MYR C 3047

Chain	Residue
C	MET83
C	SER143
C	CYS205
C	ASN208
C	PHE211
C	ILE220
C	HIS221
C	PHE224
C	LEU266
C	ILE273
C	CYS275

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MYR D 3048

Chain	Residue
D	TYR73
D	ARG81
D	PRO87
D	SER143
D	CYS205
D	ASN208
D	ALA209
D	PHE211
D	ILE220
D	HIS221
D	PHE224
D	ILE273

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:15286723

Chain	Residue	Details
A	CYS175
B	CYS175
C	CYS175
D	CYS175

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15286723

Chain	Residue	Details
A	HIS221
B	HIS221
C	HIS221
D	HIS221

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	SITE: Important for broad specificity for aliphatic long-chain acyl-CoA starter units

Chain	Residue	Details
A	CYS205
A	ALA209
B	CYS205
B	ALA209
C	CYS205
C	ALA209
D	CYS205
D	ALA209

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