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1SYH

X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 1.85 A RESOLUTION.

Functional Information from GO Data
ChainGOidnamespacecontents
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE CPW A 501
ChainResidue
AGLU10
ATHR140
ALEU189
AGLU190
AMET193
ATYR217
AHOH504
AHOH558
ATYR58
APRO86
ALEU87
ATHR88
AARG93
ALEU135
AGLY138
ASER139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsTRANSMEM: Helical
ChainResidueDetails
AALA131-VAL151
AASP204-GLY224

site_idSWS_FT_FI2
Number of Residues31
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
APHE152-VAL178
AGLU198-CYS203

site_idSWS_FT_FI3
Number of Residues15
DetailsINTRAMEM: Helical; Pore-forming
ChainResidueDetails
AARG179-ASN194

site_idSWS_FT_FI4
Number of Residues2
DetailsINTRAMEM:
ChainResidueDetails
AGLU195-ILE197

site_idSWS_FT_FI5
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
ChainResidueDetails
APRO86
AARG93
ATHR88

site_idSWS_FT_FI6
Number of Residues3
DetailsSITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
ChainResidueDetails
AARG61

site_idSWS_FT_FI7
Number of Residues1
DetailsSITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
ChainResidueDetails
AGLN241

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
AILE197

site_idSWS_FT_FI11
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN0

221051

PDB entries from 2024-06-12

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