1SFE

ADA O6-METHYLGUANINE-DNA METHYLTRANSFERASE FROM ESCHERICHIA COLI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
A	0006281	biological_process	DNA repair

Functional Information from PROSITE/UniProt

site_id	PS00374
Number of Residues	7
Details	MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV

Chain	Residue	Details
A	ILE144-VAL150

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine => ECO:0000255|PROSITE-ProRule:PRU10017, ECO:0000269|PubMed:16209950

Chain	Residue	Details
A	CYS146

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage

Chain	Residue	Details
A	LYS3

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1eh6

Chain	Residue	Details
A	ASN138
A	HIS147
A	GLU173
A	CYS146

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site_id	MCSA1
Number of Residues
Details	M-CSA 295

Chain

Residue

Details

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