1SBY
Alcohol dehydrogenase from Drosophila lebanonensis complexed with NAD+ and 2,2,2-trifluoroethanol at 1.1 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006066 | biological_process | alcohol metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006066 | biological_process | alcohol metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAD A 1255 |
| Chain | Residue |
| A | ALA12 |
| A | ALA92 |
| A | GLY93 |
| A | ILE106 |
| A | ILE136 |
| A | CYS137 |
| A | SER138 |
| A | TYR151 |
| A | LYS155 |
| A | PRO181 |
| A | GLY182 |
| A | GLY15 |
| A | ILE183 |
| A | THR184 |
| A | THR186 |
| A | LEU188 |
| A | ETF1256 |
| A | HOH1294 |
| A | HOH1302 |
| A | HOH1363 |
| A | HOH1403 |
| A | HOH1486 |
| A | GLY16 |
| A | HOH1507 |
| A | HOH1568 |
| A | ILE17 |
| A | ASP37 |
| A | TYR62 |
| A | ASP63 |
| A | VAL64 |
| A | GLY91 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ETF A 1256 |
| Chain | Residue |
| A | LEU95 |
| A | SER138 |
| A | THR140 |
| A | TYR151 |
| A | ILE183 |
| A | LEU188 |
| A | VAL189 |
| A | NAD1255 |
| site_id | AC3 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD B 2255 |
| Chain | Residue |
| B | ALA12 |
| B | GLY15 |
| B | GLY16 |
| B | ILE17 |
| B | ASP37 |
| B | ARG38 |
| B | TYR62 |
| B | ASP63 |
| B | VAL64 |
| B | GLY91 |
| B | ALA92 |
| B | GLY93 |
| B | ILE106 |
| B | ILE136 |
| B | CYS137 |
| B | SER138 |
| B | TYR151 |
| B | LYS155 |
| B | PRO181 |
| B | GLY182 |
| B | ILE183 |
| B | THR184 |
| B | THR186 |
| B | PRO187 |
| B | LEU188 |
| B | ETF2256 |
| B | HOH2362 |
| B | HOH2389 |
| B | HOH2405 |
| B | HOH2474 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ETF B 2256 |
| Chain | Residue |
| B | LEU95 |
| B | SER138 |
| B | THR140 |
| B | ILE145 |
| B | TYR151 |
| B | ILE183 |
| B | LEU188 |
| B | VAL189 |
| B | NAD2255 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvtgfnaihqVpvYSASKAAVvSFTnSLA |
| Chain | Residue | Details |
| A | SER138-ALA166 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | TYR151 | |
| B | TYR151 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10366509 |
| Chain | Residue | Details |
| A | PHE10 | |
| B | PHE10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | SER138 | |
| B | SER138 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:2707261 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 |
