1RV1

CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
B	0005634	cellular_component	nucleus
B	0043066	biological_process	negative regulation of apoptotic process
B	0051726	biological_process	regulation of cell cycle
C	0005634	cellular_component	nucleus
C	0043066	biological_process	negative regulation of apoptotic process
C	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE IMZ A 110

Chain	Residue
A	HOH10
A	HIS96
C	HOH9
C	LEU54
C	HIS96
C	TYR100
C	IMZ110
A	HOH20
A	LEU54
A	GLY58
A	ILE61
A	MET62
A	GLN72
A	HIS73
A	VAL93

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE IMZ B 110

Chain	Residue
B	LEU54
B	LEU54
B	GLY58
B	MET62
B	GLN72
B	HIS73
B	VAL93
B	HIS96
B	HIS96
B	TYR100
B	IMZ111
B	HOH120

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site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE IMZ C 110

Chain	Residue
A	LEU54
A	HIS96
A	TYR100
A	IMZ110
A	IMZ111
C	HOH9
C	LEU54
C	GLY58
C	MET62
C	GLN72
C	HIS73
C	VAL93
C	HIS96

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site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE IMZ A 111

Chain	Residue
A	HOH8
A	HOH13
A	HOH22
A	THR26
A	MET50
A	TYR100
B	THR26
B	IMZ111
C	GLU69
C	IMZ110

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site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE IMZ B 111

Chain	Residue
A	HOH22
A	THR26
A	IMZ111
B	THR26
B	MET50
B	GLU69
B	LYS70
B	GLN72
B	TYR100
B	TYR104
B	IMZ110

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