1QK4
TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE IMP COMPLEX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006178 | biological_process | guanine salvage |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0032265 | biological_process | XMP salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006178 | biological_process | guanine salvage |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0032265 | biological_process | XMP salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0006178 | biological_process | guanine salvage |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0032263 | biological_process | GMP salvage |
| C | 0032264 | biological_process | IMP salvage |
| C | 0032265 | biological_process | XMP salvage |
| C | 0046100 | biological_process | hypoxanthine metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0006178 | biological_process | guanine salvage |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0032263 | biological_process | GMP salvage |
| D | 0032264 | biological_process | IMP salvage |
| D | 0032265 | biological_process | XMP salvage |
| D | 0046100 | biological_process | hypoxanthine metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE IMP A 300 |
| Chain | Residue |
| A | GLU146 |
| A | TRP199 |
| A | ILE200 |
| A | ASP206 |
| A | HOH2105 |
| A | HOH2120 |
| A | HOH2121 |
| A | HOH2122 |
| A | HOH2123 |
| A | HOH2124 |
| A | ASP147 |
| A | ILE148 |
| A | ASP150 |
| A | THR151 |
| A | GLY152 |
| A | PHE153 |
| A | THR154 |
| A | LYS178 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE IMP B 300 |
| Chain | Residue |
| B | GLU146 |
| B | ASP147 |
| B | ILE148 |
| B | ASP150 |
| B | THR151 |
| B | GLY152 |
| B | PHE153 |
| B | THR154 |
| B | LYS178 |
| B | TRP199 |
| B | ILE200 |
| B | ASP206 |
| B | HOH2104 |
| B | HOH2105 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE IMP C 300 |
| Chain | Residue |
| C | GLU146 |
| C | ASP147 |
| C | ILE148 |
| C | ASP150 |
| C | THR151 |
| C | GLY152 |
| C | PHE153 |
| C | THR154 |
| C | LYS178 |
| C | TRP199 |
| C | ILE200 |
| C | ASP206 |
| C | HOH2134 |
| C | HOH2135 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE IMP D 300 |
| Chain | Residue |
| D | GLU146 |
| D | ASP147 |
| D | ILE148 |
| D | ASP150 |
| D | THR151 |
| D | GLY152 |
| D | PHE153 |
| D | THR154 |
| D | LYS178 |
| D | VAL198 |
| D | TRP199 |
| D | ILE200 |
| D | ASP206 |
| D | HOH2075 |
| D | HOH2120 |
| D | HOH2121 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIVDTGfT |
| Chain | Residue | Details |
| A | VAL142-THR154 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:10545171, ECO:0000269|PubMed:11188695 |
| Chain | Residue | Details |
| A | ASP150 | |
| B | ASP150 | |
| C | ASP150 | |
| D | ASP150 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS79 | |
| C | GLU146 | |
| C | LYS178 | |
| C | TRP199 | |
| D | LYS79 | |
| D | GLU146 | |
| D | LYS178 | |
| D | TRP199 | |
| A | GLU146 | |
| A | LYS178 | |
| A | TRP199 | |
| B | LYS79 | |
| B | GLU146 | |
| B | LYS178 | |
| B | TRP199 | |
| C | LYS79 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11188695 |
| Chain | Residue | Details |
| A | ASP206 | |
| B | ASP206 | |
| C | ASP206 | |
| D | ASP206 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| A | ASP147 | |
| A | ASP150 | |
| A | GLU146 | |
| A | LYS178 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| B | ASP147 | |
| B | ASP150 | |
| B | GLU146 | |
| B | LYS178 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| C | ASP147 | |
| C | ASP150 | |
| C | GLU146 | |
| C | LYS178 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| D | ASP147 | |
| D | ASP150 | |
| D | GLU146 | |
| D | LYS178 |
| site_id | CSA5 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| A | ARG182 | |
| A | ASP147 | |
| A | ASP150 | |
| A | GLU146 | |
| A | LYS178 |
| site_id | CSA6 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| B | ARG182 | |
| B | ASP147 | |
| B | ASP150 | |
| B | GLU146 | |
| B | LYS178 |
| site_id | CSA7 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| C | ARG182 | |
| C | ASP147 | |
| C | ASP150 | |
| C | GLU146 | |
| C | LYS178 |
