Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0004866 | molecular_function | endopeptidase inhibitor activity |
| C | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| C | 0005737 | cellular_component | cytoplasm |
| D | 0004866 | molecular_function | endopeptidase inhibitor activity |
| D | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| D | 0005737 | cellular_component | cytoplasm |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 459 |
| Chain | Residue |
| A | HOH606 |
| B | LYS232 |
| B | ARG234 |
| B | HOH576 |
| B | HOH590 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 460 |
| Chain | Residue |
| A | LYS232 |
| A | ARG234 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 461 |
| Chain | Residue |
| B | ASP383 |
| B | HOH541 |
| B | HOH626 |
| D | HIS62 |
| D | ARG64 |
| B | ASN381 |
| B | ARG382 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 462 |
| Chain | Residue |
| A | ARG382 |
| A | ASP383 |
| C | HIS62 |
| C | ARG64 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 463 |
| Chain | Residue |
| A | HIS213 |
| A | HIS214 |
| A | HIS215 |
| A | HIS217 |
| B | HIS213 |
| B | HIS215 |
| B | HIS217 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GAI B 464 |
| Chain | Residue |
| A | GLU291 |
| A | LYS294 |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LGHALAVVGNA |
| Chain | Residue | Details |
| A | LEU338-ALA348 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ALA243 | |
| A | HIS340 | |
| A | ASN360 | |
| B | ALA243 | |
| B | HIS340 | |
| B | ASN360 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by SspA => ECO:0000250 |
| Chain | Residue | Details |
| A | PHE219 | |
| B | PHE219 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 15518582, 12874290 |
| Chain | Residue | Details |
| A | HIS340 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 805 |
| Chain | Residue | Details |
| A | GLN237 | electrostatic stabiliser |
| A | ALA243 | nucleofuge, nucleophile, proton acceptor, proton donor |
| A | HIS340 | proton acceptor, proton donor |
| A | ASN360 | electrostatic stabiliser, modifies pKa |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 805 |
| Chain | Residue | Details |
| B | GLN237 | electrostatic stabiliser |
| B | ALA243 | nucleofuge, nucleophile, proton acceptor, proton donor |
| B | HIS340 | proton acceptor, proton donor |
| B | ASN360 | electrostatic stabiliser, modifies pKa |
