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1P1W

Crystal structure of the GluR2 ligand-binding core (S1S2J) with the L483Y and L650T mutations and in complex with AMPA

Functional Information from GO Data
ChainGOidnamespacecontents
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 501
ChainResidue
BASP139
BSER140
BLYS144
BARG148
BHOH515
BHOH516
BHOH611

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 502
ChainResidue
AARG148
AHOH573
AHOH587
ASER140
ALYS144

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE AMQ B 427
ChainResidue
BTYR61
BPRO89
BLEU90
BTHR91
BARG96
BGLY141
BSER142
BTHR143
BLEU192
BGLU193
BMET196
BTYR220
BHOH586
BHOH587

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE AMQ A 428
ChainResidue
ATYR61
APRO89
ALEU90
ATHR91
AARG96
AGLY141
ASER142
ATHR143
ALEU192
AGLU193
AMET196
ATYR220
AHOH582
AHOH583

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
ChainResidueDetails
BSER142
BTHR143
BGLU193
BPRO89
BTHR91
BARG96
APRO89
ATHR91
AARG96
ASER142
ATHR143
AGLU193

site_idSWS_FT_FI2
Number of Residues6
DetailsSITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
ChainResidueDetails
ALYS240
BARG64
BARG148
BLYS240
AARG64
AARG148

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
ChainResidueDetails
AILE121
BILE121

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
ChainResidueDetails
ASER150
BSER150

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
ChainResidueDetails
ASER184
BSER184

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN3
BASN3

221051

PDB entries from 2024-06-12

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