1OXL
INHIBITION OF PHOSPHOLIPASE A2 (PLA2) BY (2-CARBAMOYLMETHYL-5-PROPYL-OCTAHYDRO-INDOL-7-YL)-ACETIC ACID (INDOLE): CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN PLA2 FROM RUSSELL'S VIPER AND INDOLE AT 1.8 RESOLUTION
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004623 | molecular_function | phospholipase A2 activity |
A | 0005509 | molecular_function | calcium ion binding |
A | 0005543 | molecular_function | phospholipid binding |
A | 0005576 | cellular_component | extracellular region |
A | 0006644 | biological_process | phospholipid metabolic process |
A | 0016042 | biological_process | lipid catabolic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0035821 | biological_process | modulation of process of another organism |
A | 0042130 | biological_process | negative regulation of T cell proliferation |
A | 0046872 | molecular_function | metal ion binding |
A | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
A | 0050482 | biological_process | arachidonic acid secretion |
A | 0090729 | molecular_function | toxin activity |
B | 0004623 | molecular_function | phospholipase A2 activity |
B | 0005509 | molecular_function | calcium ion binding |
B | 0005543 | molecular_function | phospholipid binding |
B | 0005576 | cellular_component | extracellular region |
B | 0006644 | biological_process | phospholipid metabolic process |
B | 0016042 | biological_process | lipid catabolic process |
B | 0016787 | molecular_function | hydrolase activity |
B | 0035821 | biological_process | modulation of process of another organism |
B | 0042130 | biological_process | negative regulation of T cell proliferation |
B | 0046872 | molecular_function | metal ion binding |
B | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
B | 0050482 | biological_process | arachidonic acid secretion |
B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CO3 B 301 |
Chain | Residue |
A | PHE124 |
B | ARG107 |
B | GLN108 |
B | HOH443 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CO3 B 302 |
Chain | Residue |
B | ARG43 |
B | HOH416 |
B | HOH470 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 401 |
Chain | Residue |
B | LYS115 |
B | LYS116 |
B | HOH458 |
B | HOH555 |
A | ARG77 |
B | SER114 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE IDA A 501 |
Chain | Residue |
A | LEU2 |
A | PHE5 |
A | GLY30 |
A | TRP31 |
A | HIS48 |
A | ASP49 |
A | TYR52 |
A | HOH518 |
A | HOH614 |
A | HOH615 |
A | HOH616 |
A | HOH619 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P14418 |
Chain | Residue | Details |
A | HIS48 | |
A | ASP99 | |
B | HIS48 | |
B | ASP99 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|Ref.12, ECO:0007744|PDB:1TGM |
Chain | Residue | Details |
A | TYR28 | |
A | GLY30 | |
A | GLY32 | |
B | GLY32 | |
B | ASP49 | |
A | ASP49 | |
B | TYR28 | |
B | GLY30 |