1NQ1

TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 4HY A 500

Chain	Residue
A	ILE276
A	MET442
A	PHE455
A	MET313
A	ALA317
A	ARG320
A	LEU330
A	ASN331
A	GLY344
A	ILE353
A	HIS435

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ARS A 600

Chain	Residue
A	ASP427
A	CYS434

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ARS A 601

Chain	Residue
A	CYS434

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15466465, ECO:0007744|PDB:1Y0X

Chain	Residue	Details
A	ARG282
A	ASN331
A	HIS435

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