1NFB
Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with 6Cl-IMP and NAD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003938 | molecular_function | IMP dehydrogenase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005778 | cellular_component | peroxisomal membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0034774 | cellular_component | secretory granule lumen |
| A | 0046651 | biological_process | lymphocyte proliferation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071353 | biological_process | cellular response to interleukin-4 |
| A | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003938 | molecular_function | IMP dehydrogenase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005778 | cellular_component | peroxisomal membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006183 | biological_process | GTP biosynthetic process |
| B | 0007623 | biological_process | circadian rhythm |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0034774 | cellular_component | secretory granule lumen |
| B | 0046651 | biological_process | lymphocyte proliferation |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071353 | biological_process | cellular response to interleukin-4 |
| B | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CPR A 631 |
| Chain | Residue |
| A | SER68 |
| A | GLY366 |
| A | GLY387 |
| A | SER388 |
| A | TYR411 |
| A | NAD701 |
| A | HOH744 |
| A | MET70 |
| A | GLY328 |
| A | SER329 |
| A | ILE330 |
| A | CYS331 |
| A | GLU335 |
| A | ASP364 |
| A | GLY365 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CPR B 631 |
| Chain | Residue |
| B | SER68 |
| B | MET70 |
| B | GLY328 |
| B | SER329 |
| B | ILE330 |
| B | CYS331 |
| B | GLU335 |
| B | ASP364 |
| B | GLY365 |
| B | GLY366 |
| B | GLY387 |
| B | SER388 |
| B | TYR411 |
| B | NAD702 |
| B | HOH720 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NAD A 701 |
| Chain | Residue |
| A | THR45 |
| A | THR252 |
| A | HIS253 |
| A | ASP274 |
| A | SER275 |
| A | SER276 |
| A | PHE282 |
| A | ASN303 |
| A | ARG322 |
| A | HIS466 |
| A | GLN469 |
| A | CPR631 |
| A | HOH727 |
| A | HOH731 |
| A | HOH733 |
| A | HOH734 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE NAD B 702 |
| Chain | Residue |
| B | THR45 |
| B | THR252 |
| B | HIS253 |
| B | ASP274 |
| B | SER275 |
| B | SER276 |
| B | PHE282 |
| B | ASN303 |
| B | ARG322 |
| B | HIS466 |
| B | GLN469 |
| B | CPR631 |
| B | HOH731 |
| B | HOH733 |
| B | HOH734 |
| B | HOH744 |
| B | HOH745 |
Functional Information from PROSITE/UniProt
| site_id | PS00487 |
| Number of Residues | 13 |
| Details | IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRVGMGsGSICiT |
| Chain | Residue | Details |
| A | LEU321-THR333 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:10097070 |
| Chain | Residue | Details |
| A | CYS331 | |
| B | CYS331 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03156 |
| Chain | Residue | Details |
| A | ARG429 | |
| B | ARG429 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP274 | |
| A | ASP364 | |
| A | GLY387 | |
| B | ASP274 | |
| B | ASP364 | |
| B | GLY387 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03156 |
| Chain | Residue | Details |
| A | GLY324 | |
| B | TYR411 | |
| B | GLN441 | |
| B | GLU500 | |
| B | GLY501 | |
| B | GLY502 | |
| A | SER329 | |
| A | TYR411 | |
| A | GLN441 | |
| A | GLU500 | |
| A | GLY501 | |
| A | GLY502 | |
| B | GLY324 | |
| B | SER329 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|Ref.28 |
| Chain | Residue | Details |
| A | GLY326 | |
| A | GLY328 | |
| A | CYS331 | |
| B | GLY326 | |
| B | GLY328 | |
| B | CYS331 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER122 | |
| B | SER122 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER160 | |
| B | SER160 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| A | TYR400 | |
| B | TYR400 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER416 | |
| B | SER416 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS511 | |
| B | LYS511 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS195 | |
| A | LYS208 | |
| A | LYS438 | |
| B | LYS195 | |
| B | LYS208 | |
| B | LYS438 |
