1N7R

Streptococcus pneumoniae Hyaluronate Lyase W291A/W292A/F343V Mutant complex with hexasaccharide hyaluronan

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005576	cellular_component	extracellular region
A	0005975	biological_process	carbohydrate metabolic process
A	0016829	molecular_function	lyase activity
A	0030246	molecular_function	carbohydrate binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:10716923

Chain	Residue	Details
A	ASN349
A	HIS399
A	TYR408

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 439

Chain	Residue	Details
A	ASN349	modifies pKa
A	HIS399	modifies pKa
A	TYR408	proton shuttle (general acid/base)
A	ARG462	modifies pKa

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