1M7G
Crystal structure of APS kinase from Penicillium Chrysogenum: Ternary structure with ADP and APS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000103 | biological_process | sulfate assimilation |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004020 | molecular_function | adenylylsulfate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0050428 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process |
| A | 0070814 | biological_process | hydrogen sulfide biosynthetic process |
| B | 0000103 | biological_process | sulfate assimilation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004020 | molecular_function | adenylylsulfate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016310 | biological_process | phosphorylation |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019344 | biological_process | cysteine biosynthetic process |
| B | 0050428 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process |
| B | 0070814 | biological_process | hydrogen sulfide biosynthetic process |
| C | 0000103 | biological_process | sulfate assimilation |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004020 | molecular_function | adenylylsulfate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009086 | biological_process | methionine biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016310 | biological_process | phosphorylation |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019344 | biological_process | cysteine biosynthetic process |
| C | 0050428 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process |
| C | 0070814 | biological_process | hydrogen sulfide biosynthetic process |
| D | 0000103 | biological_process | sulfate assimilation |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004020 | molecular_function | adenylylsulfate kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009086 | biological_process | methionine biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016310 | biological_process | phosphorylation |
| D | 0016740 | molecular_function | transferase activity |
| D | 0019344 | biological_process | cysteine biosynthetic process |
| D | 0050428 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process |
| D | 0070814 | biological_process | hydrogen sulfide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2001 |
| Chain | Residue |
| A | THR13 |
| D | VAL142 |
| D | HOH1356 |
| A | ARG14 |
| A | ARG17 |
| A | HOH2023 |
| A | HOH2027 |
| A | HOH2081 |
| A | HOH2140 |
| A | HOH2187 |
| D | PRO141 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2002 |
| Chain | Residue |
| A | ARG14 |
| A | ARG17 |
| A | ARG21 |
| A | LYS203 |
| A | HOH2145 |
| D | HOH1474 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2003 |
| Chain | Residue |
| A | ARG110 |
| A | ARG113 |
| A | ASP114 |
| A | GLU135 |
| A | PRO175 |
| A | ALA176 |
| A | ASN177 |
| A | HOH2120 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2004 |
| Chain | Residue |
| B | ARG110 |
| B | ARG113 |
| B | ASP114 |
| B | GLU135 |
| B | PRO175 |
| B | ALA176 |
| B | ASN177 |
| B | HOH2183 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2005 |
| Chain | Residue |
| B | ASN177 |
| C | ARG14 |
| C | ARG17 |
| C | ARG21 |
| C | THR202 |
| C | LYS203 |
| C | HOH2153 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2006 |
| Chain | Residue |
| C | ARG110 |
| C | ARG113 |
| C | GLU135 |
| C | PRO175 |
| C | ALA176 |
| C | ASN177 |
| C | HOH2134 |
| site_id | AC7 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE AV2 A 1301 |
| Chain | Residue |
| A | LEU33 |
| A | ALA35 |
| A | SER36 |
| A | GLY37 |
| A | LYS38 |
| A | SER39 |
| A | THR40 |
| A | ARG148 |
| A | ASN184 |
| A | LEU187 |
| A | VAL189 |
| A | HOH2009 |
| A | HOH2061 |
| A | HOH2077 |
| A | HOH2114 |
| A | HOH2117 |
| A | HOH2160 |
| A | HOH2174 |
| A | HOH2175 |
| A | HOH2232 |
| C | ARG148 |
| C | PRO150 |
| C | AV21306 |
| C | HOH2125 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADX A 1302 |
| Chain | Residue |
| A | SER34 |
| A | ARG66 |
| A | PHE75 |
| A | ARG80 |
| A | ASN83 |
| A | ILE84 |
| A | PHE105 |
| A | ILE106 |
| A | SER107 |
| A | PRO108 |
| A | LEU153 |
| A | LYS163 |
| A | GLU164 |
| A | PHE165 |
| A | THR166 |
| A | HOH2009 |
| A | HOH2020 |
| A | HOH2038 |
| A | HOH2057 |
| A | HOH2100 |
| A | HOH2136 |
| site_id | AC9 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ADP B 1304 |
| Chain | Residue |
| B | ARG148 |
| B | LEU187 |
| B | HOH2031 |
| B | HOH2044 |
| B | HOH2071 |
| B | HOH2076 |
| B | HOH2078 |
| B | HOH2081 |
| B | HOH2132 |
| B | HOH2133 |
| B | HOH2138 |
| B | HOH2166 |
| D | GLU186 |
| B | LEU33 |
| B | ALA35 |
| B | SER36 |
| B | GLY37 |
| B | LYS38 |
| B | SER39 |
| B | THR40 |
| site_id | BC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE ADX B 1305 |
| Chain | Residue |
| B | SER34 |
| B | ARG66 |
| B | PHE75 |
| B | ARG80 |
| B | ASN83 |
| B | ILE84 |
| B | PHE105 |
| B | ILE106 |
| B | SER107 |
| B | PRO108 |
| B | LYS151 |
| B | LEU153 |
| B | LYS163 |
| B | GLU164 |
| B | PHE165 |
| B | THR166 |
| B | HOH2019 |
| B | HOH2031 |
| B | HOH2036 |
| B | HOH2109 |
| B | HOH2123 |
| B | HOH2178 |
| B | HOH2198 |
| site_id | BC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE AV2 C 1306 |
| Chain | Residue |
| A | ARG148 |
| A | PRO150 |
| A | AV21301 |
| A | HOH2090 |
| A | HOH2102 |
| A | HOH2160 |
| C | LEU33 |
| C | ALA35 |
| C | SER36 |
| C | GLY37 |
| C | LYS38 |
| C | SER39 |
| C | THR40 |
| C | ARG148 |
| C | ASN184 |
| C | LEU187 |
| C | VAL189 |
| C | HOH2014 |
| C | HOH2057 |
| C | HOH2077 |
| C | HOH2137 |
| C | HOH2168 |
| C | HOH2169 |
| site_id | BC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ADX C 1307 |
| Chain | Residue |
| C | SER34 |
| C | ARG66 |
| C | PHE75 |
| C | ARG80 |
| C | ASN83 |
| C | ILE84 |
| C | PHE105 |
| C | ILE106 |
| C | SER107 |
| C | PRO108 |
| C | LEU153 |
| C | LYS163 |
| C | GLU164 |
| C | PHE165 |
| C | THR166 |
| C | HOH2014 |
| C | HOH2024 |
| C | HOH2044 |
| C | HOH2091 |
| C | HOH2092 |
| C | HOH2133 |
| C | HOH2155 |
| site_id | BC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ADP D 1309 |
| Chain | Residue |
| B | GLU186 |
| B | HOH2195 |
| D | LEU33 |
| D | ALA35 |
| D | SER36 |
| D | GLY37 |
| D | LYS38 |
| D | SER39 |
| D | THR40 |
| D | ARG148 |
| D | LEU187 |
| D | HOH1323 |
| D | HOH1344 |
| D | HOH1362 |
| D | HOH1418 |
| D | HOH1435 |
| D | HOH1440 |
| D | HOH1447 |
| D | HOH1458 |
| D | HOH1472 |
| site_id | BC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADX D 1310 |
| Chain | Residue |
| D | SER34 |
| D | ARG66 |
| D | PHE75 |
| D | ARG80 |
| D | ASN83 |
| D | ILE84 |
| D | PHE105 |
| D | ILE106 |
| D | SER107 |
| D | PRO108 |
| D | LEU153 |
| D | LYS163 |
| D | GLU164 |
| D | PHE165 |
| D | THR166 |
| D | HOH1321 |
| D | HOH1323 |
| D | HOH1332 |
| D | HOH1371 |
| D | HOH1424 |
| D | HOH1441 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL C 2010 |
| Chain | Residue |
| A | SER2 |
| A | THR3 |
| A | HOH2052 |
| C | PHE7 |
| C | ARG21 |
| C | LYS203 |
| C | TYR205 |
| C | HOH2059 |
| C | HOH2163 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 2011 |
| Chain | Residue |
| B | PRO188 |
| B | VAL189 |
| B | GLN190 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Phosphoserine intermediate => ECO:0000250 |
| Chain | Residue | Details |
| A | SER107 | |
| B | SER107 | |
| C | SER107 | |
| D | SER107 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY32 | |
| B | GLY32 | |
| C | GLY32 | |
| D | GLY32 |
