1M5C
X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH Br-HIBO AT 1.65 A RESOLUTION
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE BRH A 611 |
| Chain | Residue |
| A | GLU13 |
| A | THR174 |
| A | LEU192 |
| A | GLU193 |
| A | TYR220 |
| A | HOH617 |
| A | HOH634 |
| A | HOH637 |
| A | HOH751 |
| A | TYR61 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO |
| Chain | Residue | Details |
| A | SER142 | |
| A | THR143 | |
| A | GLU193 | |
| A | PRO89 | |
| A | THR91 | |
| A | ARG96 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ARG148 | |
| A | LYS240 | |
| A | ARG64 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ILE121 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 |
| Chain | Residue | Details |
| A | SER150 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 |
| Chain | Residue | Details |
| A | SER184 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN3 |
