1M13

Crystal Structure of the Human Pregane X Receptor Ligand Binding Domain in Complex with Hyperforin, a Constituent of St. John's Wort

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HYF A 435

Chain	Residue
A	LEU209
A	MET323
A	HIS407
A	ILE414
A	PHE420
A	HOH471
A	HOH504
A	LEU240
A	MET243
A	SER247
A	PHE281
A	CYS284
A	GLN285
A	PHE288
A	TRP299

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:12578355, ECO:0007744|PDB:1M13

Chain	Residue	Details
A	SER247
A	HIS407
A	GLN285

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