1LDA
CRYSTAL STRUCTURE OF THE E. COLI GLYCEROL FACILITATOR (GLPF) WITHOUT SUBSTRATE GLYCEROL
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005372 | molecular_function | water transmembrane transporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006833 | biological_process | water transport |
| A | 0015168 | molecular_function | glycerol transmembrane transporter activity |
| A | 0015254 | molecular_function | glycerol channel activity |
| A | 0015267 | molecular_function | channel activity |
| A | 0015791 | biological_process | polyol transmembrane transport |
| A | 0015793 | biological_process | glycerol transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071288 | biological_process | cellular response to mercury ion |
Functional Information from PROSITE/UniProt
| site_id | PS00221 |
| Number of Residues | 9 |
| Details | MIP MIP family signature. HLNPAVTIA |
| Chain | Residue | Details |
| A | HIS66-ALA74 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:11039922 |
| Chain | Residue | Details |
| A | MET1-SER5 | |
| A | GLY61-SER63 | |
| A | ALA79-ARG84 | |
| A | GLY170-PRO177 | |
| A | ILE255-LEU281 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=M1 => ECO:0000269|PubMed:11039922 |
| Chain | Residue | Details |
| A | THR6-VAL34 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 55 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:11039922 |
| Chain | Residue | Details |
| A | ALA35-PHE39 | |
| A | TYR109-ILE143 | |
| A | GLY195-THR198 | |
| A | ALA217-PRO231 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=M2 => ECO:0000269|PubMed:11039922 |
| Chain | Residue | Details |
| A | GLY40-ALA60 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:11039922 |
| Chain | Residue | Details |
| A | GLY64-LEU67 | |
| A | GLY199-MET202 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | INTRAMEM: Helical; Name=M3 => ECO:0000269|PubMed:11039922 |
| Chain | Residue | Details |
| A | ASN68-PHE78 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=M4 => ECO:0000269|PubMed:11039922 |
| Chain | Residue | Details |
| A | LYS85-TYR108 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=M5 => ECO:0000269|PubMed:11039922 |
| Chain | Residue | Details |
| A | ASN144-ASP169 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=M6 => ECO:0000269|PubMed:11039922 |
| Chain | Residue | Details |
| A | LEU178-MET194 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 13 |
| Details | INTRAMEM: Helical; Name=M7 => ECO:0000269|PubMed:11039922 |
| Chain | Residue | Details |
| A | ASN203-LEU216 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=M8 => ECO:0000269|PubMed:11039922 |
| Chain | Residue | Details |
| A | TYR232-LEU254 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11039922, ECO:0000269|PubMed:11964478, ECO:0007744|PDB:1FX8, ECO:0007744|PDB:1LDF |
| Chain | Residue | Details |
| A | HIS66 | |
| A | ASN203 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11039922, ECO:0000269|PubMed:11964478, ECO:0007744|PDB:1FX8 |
| Chain | Residue | Details |
| A | TYR138 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11039922, ECO:0007744|PDB:1FX8 |
| Chain | Residue | Details |
| A | GLY199 | |
| A | ARG206 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | SITE: Substrate discrimination => ECO:0000305|PubMed:11101882 |
| Chain | Residue | Details |
| A | TRP48 | |
| A | PHE200 | |
| A | ARG206 |
