1L3I
MT0146, THE PRECORRIN-6Y METHYLTRANSFERASE (CBIT) HOMOLOG FROM M. THERMOAUTOTROPHICUM, ADOHCY BINARY COMPLEX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008276 | molecular_function | protein methyltransferase activity |
| A | 0009236 | biological_process | cobalamin biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0043776 | molecular_function | cobalt-precorrin-6B C5-methyltransferase activity |
| A | 0046140 | biological_process | corrin biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008276 | molecular_function | protein methyltransferase activity |
| B | 0009236 | biological_process | cobalamin biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0043776 | molecular_function | cobalt-precorrin-6B C5-methyltransferase activity |
| B | 0046140 | biological_process | corrin biosynthetic process |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0008276 | molecular_function | protein methyltransferase activity |
| C | 0009236 | biological_process | cobalamin biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0032259 | biological_process | methylation |
| C | 0043776 | molecular_function | cobalt-precorrin-6B C5-methyltransferase activity |
| C | 0046140 | biological_process | corrin biosynthetic process |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0008276 | molecular_function | protein methyltransferase activity |
| D | 0009236 | biological_process | cobalamin biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0032259 | biological_process | methylation |
| D | 0043776 | molecular_function | cobalt-precorrin-6B C5-methyltransferase activity |
| D | 0046140 | biological_process | corrin biosynthetic process |
| E | 0008168 | molecular_function | methyltransferase activity |
| E | 0008276 | molecular_function | protein methyltransferase activity |
| E | 0009236 | biological_process | cobalamin biosynthetic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0032259 | biological_process | methylation |
| E | 0043776 | molecular_function | cobalt-precorrin-6B C5-methyltransferase activity |
| E | 0046140 | biological_process | corrin biosynthetic process |
| F | 0008168 | molecular_function | methyltransferase activity |
| F | 0008276 | molecular_function | protein methyltransferase activity |
| F | 0009236 | biological_process | cobalamin biosynthetic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0032259 | biological_process | methylation |
| F | 0043776 | molecular_function | cobalt-precorrin-6B C5-methyltransferase activity |
| F | 0046140 | biological_process | corrin biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE SAH A 801 |
| Chain | Residue |
| A | PRO14 |
| A | VAL47 |
| A | ASP62 |
| A | ARG63 |
| A | ALA67 |
| A | GLY89 |
| A | ASP90 |
| A | ALA91 |
| A | GLY107 |
| A | GLY108 |
| A | SER109 |
| A | PRO16 |
| A | GLY110 |
| A | GLU112 |
| A | HOH824 |
| A | HOH845 |
| A | HOH865 |
| A | HOH870 |
| A | THR17 |
| A | GLY41 |
| A | CYS42 |
| A | GLY43 |
| A | THR44 |
| A | GLY45 |
| A | GLY46 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE SAH B 802 |
| Chain | Residue |
| B | PRO14 |
| B | GLY15 |
| B | PRO16 |
| B | THR17 |
| B | GLY41 |
| B | CYS42 |
| B | GLY43 |
| B | THR44 |
| B | GLY45 |
| B | GLY46 |
| B | VAL47 |
| B | ASP62 |
| B | ARG63 |
| B | ALA67 |
| B | GLY89 |
| B | ASP90 |
| B | ALA91 |
| B | GLY107 |
| B | GLY108 |
| B | SER109 |
| B | GLY110 |
| B | GLU112 |
| B | HOH825 |
| B | HOH847 |
| B | HOH871 |
| B | HOH910 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE SAH C 803 |
| Chain | Residue |
| C | PRO14 |
| C | PRO16 |
| C | THR17 |
| C | GLY41 |
| C | CYS42 |
| C | GLY43 |
| C | THR44 |
| C | GLY45 |
| C | GLY46 |
| C | VAL47 |
| C | ASP62 |
| C | ARG63 |
| C | GLY89 |
| C | ASP90 |
| C | ALA91 |
| C | GLY107 |
| C | GLY108 |
| C | SER109 |
| C | GLY110 |
| C | GLU112 |
| C | HOH852 |
| C | HOH873 |
| C | HOH897 |
| C | HOH935 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE SAH D 804 |
| Chain | Residue |
| D | PRO14 |
| D | GLY15 |
| D | PRO16 |
| D | THR17 |
| D | GLY41 |
| D | CYS42 |
| D | GLY43 |
| D | THR44 |
| D | GLY45 |
| D | GLY46 |
| D | VAL47 |
| D | ASP62 |
| D | ARG63 |
| D | GLY89 |
| D | ASP90 |
| D | ALA91 |
| D | GLY107 |
| D | GLY108 |
| D | SER109 |
| D | GLY110 |
| D | GLU112 |
| D | HOH823 |
| D | HOH862 |
| D | HOH880 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE SAH E 805 |
| Chain | Residue |
| E | PRO14 |
| E | PRO16 |
| E | THR17 |
| E | GLY41 |
| E | CYS42 |
| E | GLY43 |
| E | THR44 |
| E | GLY45 |
| E | GLY46 |
| E | VAL47 |
| E | ASP62 |
| E | ARG63 |
| E | GLY89 |
| E | ASP90 |
| E | ALA91 |
| E | GLY107 |
| E | GLY108 |
| E | SER109 |
| E | GLY110 |
| E | GLU112 |
| E | HOH827 |
| E | HOH848 |
| E | HOH883 |
| E | HOH903 |
| site_id | AC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE SAH F 806 |
| Chain | Residue |
| F | PRO14 |
| F | PRO16 |
| F | THR17 |
| F | GLY41 |
| F | CYS42 |
| F | GLY43 |
| F | THR44 |
| F | GLY45 |
| F | GLY46 |
| F | VAL47 |
| F | ASP62 |
| F | ARG63 |
| F | ALA67 |
| F | GLY89 |
| F | ASP90 |
| F | ALA91 |
| F | GLY107 |
| F | GLY108 |
| F | SER109 |
| F | GLY110 |
| F | GLU112 |
| F | HOH828 |
Functional Information from PROSITE/UniProt
| site_id | PS00591 |
| Number of Residues | 11 |
| Details | GH10_1 Glycosyl hydrolases family 10 (GH10) active site. GFDVnITELNI |
| Chain | Residue | Details |
| A | GLY151-ILE161 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00786, ECO:0000269|PubMed:12429089 |
| Chain | Residue | Details |
| A | THR17 | |
| A | ASP62 | |
| E | THR17 | |
| E | ASP62 | |
| E | ALA91 | |
| F | THR17 | |
| F | ASP62 | |
| F | ALA91 | |
| A | ALA91 | |
| B | THR17 | |
| B | ASP62 | |
| B | ALA91 | |
| C | THR17 | |
| C | ASP62 | |
| C | ALA91 | |
| D | THR17 | |
| D | ASP62 | |
| D | ALA91 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY41 | |
| B | GLY41 | |
| C | GLY41 | |
| D | GLY41 | |
| E | GLY41 | |
| F | GLY41 |
