Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0006508 | biological_process | proteolysis |
A | 0007596 | biological_process | blood coagulation |
B | 0004252 | molecular_function | serine-type endopeptidase activity |
B | 0005509 | molecular_function | calcium ion binding |
B | 0006508 | biological_process | proteolysis |
B | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE C02 B 1 |
Chain | Residue |
B | HIS57 |
B | TRP215 |
B | GLY216 |
B | GLU217 |
B | GLY219 |
B | CYS220 |
B | GLY226 |
B | TYR60 |
B | TRP60 |
B | GLU97 |
B | ASN98 |
B | LEU99 |
B | ASP189 |
B | ALA190 |
B | SER214 |
site_id | AC2 |
Number of Residues | 20 |
Details | BINDING SITE FOR CHAIN C OF HIRUDIN IIB |
Chain | Residue |
B | PHE34 |
B | GLN38 |
B | LEU40 |
B | ARG67 |
B | ARG73 |
B | THR74 |
B | ARG75 |
B | ARG75 |
B | TYR76 |
B | GLU80 |
B | LYS81 |
B | ILE82 |
B | MET84 |
C | HOH577 |
C | HOH586 |
C | HOH591 |
C | HOH617 |
C | HOH725 |
C | HOH760 |
C | HOH761 |
Functional Information from PROSITE/UniProt
site_id | PS00134 |
Number of Residues | 6 |
Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
Chain | Residue | Details |
B | LEU53-CYS58 | |
site_id | PS00135 |
Number of Residues | 12 |
Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
Chain | Residue | Details |
B | ASP189-VAL200 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: Sulfotyrosine => ECO:0000250 |
Chain | Residue | Details |
C | TYS263 | |
B | ASP102 | |
B | SER195 | |
Chain | Residue | Details |
B | ASN60 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | ASP102 | |
B | HIS57 | |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | SER195 | |
B | GLY196 | |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | SER195 | |
B | GLY193 | |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | ASP102 | |
B | SER195 | |
B | GLY193 | |
B | HIS57 | |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | ASP102 | |
B | SER195 | |
B | HIS57 | |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | ASP102 | |
B | SER195 | |
B | HIS57 | |
B | GLY196 | |