1KGJ

Rat transthyretin (also called prealbumin) complex with 3',5'-dibromoflavone (EMD21388)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006144	biological_process	purine nucleobase metabolic process
A	0007165	biological_process	signal transduction
A	0032991	cellular_component	protein-containing complex
A	0042403	biological_process	thyroid hormone metabolic process
A	0042562	molecular_function	hormone binding
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0070324	molecular_function	thyroid hormone binding
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006144	biological_process	purine nucleobase metabolic process
B	0007165	biological_process	signal transduction
B	0032991	cellular_component	protein-containing complex
B	0042403	biological_process	thyroid hormone metabolic process
B	0042562	molecular_function	hormone binding
B	0042802	molecular_function	identical protein binding
B	0044877	molecular_function	protein-containing complex binding
B	0070324	molecular_function	thyroid hormone binding
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006144	biological_process	purine nucleobase metabolic process
C	0007165	biological_process	signal transduction
C	0032991	cellular_component	protein-containing complex
C	0042403	biological_process	thyroid hormone metabolic process
C	0042562	molecular_function	hormone binding
C	0042802	molecular_function	identical protein binding
C	0044877	molecular_function	protein-containing complex binding
C	0070324	molecular_function	thyroid hormone binding
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006144	biological_process	purine nucleobase metabolic process
D	0007165	biological_process	signal transduction
D	0032991	cellular_component	protein-containing complex
D	0042403	biological_process	thyroid hormone metabolic process
D	0042562	molecular_function	hormone binding
D	0042802	molecular_function	identical protein binding
D	0044877	molecular_function	protein-containing complex binding
D	0070324	molecular_function	thyroid hormone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE FL8 C 128

Chain	Residue
A	LYS15
C	ALA508
C	LEU510
C	SER517
C	THR518
C	THR519
C	HOH761
C	HOH872
C	HOH913
A	LEU17
A	ALA108
A	LEU110
A	SER117
A	THR119
C	LYS415
C	LEU417
C	THR506

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FL8 B 328

Chain	Residue
B	LYS215
B	LEU217
B	ALA308
B	SER317
B	THR319
D	LEU617
D	ALA708
D	LEU710
D	SER717

---

Functional Information from PROSITE/UniProt

site_id	PS00768
Number of Residues	16
Details	TRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAvdVaV

Chain	Residue	Details
A	LYS15-VAL30

---

site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS

Chain	Residue	Details
A	TYR105-SER117

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|PubMed:11995998, ECO:0007744|PDB:1KGI

Chain	Residue	Details
A	LYS15
C	LYS415
D	LYS615
C	SER517
D	SER717
A	SER117
B	LYS215
B	SER317

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:11995998

Chain	Residue	Details
A	GLU54
B	GLU254
C	GLU454
D	GLU654

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Sulfocysteine => ECO:0000250|UniProtKB:P02766

Chain	Residue	Details
B	CYS210
C	CYS410
D	CYS610
A	CYS10

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: 4-carboxyglutamate => ECO:0000250|UniProtKB:P02766

Chain	Residue	Details
A	GLU42
B	GLU242
C	GLU442
D	GLU642

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903

Chain	Residue	Details
A	SER52
B	SER252
C	SER452
D	SER652

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN98
B	ASN298
C	ASN498
D	ASN698

---